AI Article Synopsis
- In sexually reproducing organisms, retinoic acid (RA) triggers the transition from mitosis to meiosis by activating the transcription of Stra8, which is crucial for meiotic DNA replication.
- RA also induces the transcription of Rec8, a key component of the cohesin complex necessary for proper chromosome alignment and segregation during meiosis.
- The induction of both Stra8 and Rec8 by RA is dependent on the Dazl factor, highlighting the roles of RA and Dazl in early meiosis and suggesting further research opportunities into Rec8's function.
Article Abstract
In all sexually reproducing organisms, cells of the germ line must transition from mitosis to meiosis. In mice, retinoic acid (RA), the extrinsic signal for meiotic initiation, activates transcription of Stra8, which is required for meiotic DNA replication and the subsequent processes of meiotic prophase. Here we report that RA also activates transcription of Rec8, which encodes a component of the cohesin complex that accumulates during meiotic S phase, and which is essential for chromosome synapsis and segregation. This RA induction of Rec8 occurs in parallel with the induction of Stra8, and independently of Stra8 function, and it is conserved between the sexes. Further, RA induction of Rec8, like that of Stra8, requires the germ-cell-intrinsic competence factor Dazl. Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125102 | PMC |
| http://dx.doi.org/10.1371/journal.pgen.1004541 | DOI Listing |
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