Background: Pulp necrosis as a result of trauma is common in almost all intruded teeth, and the ideal treatment method for intruded immature and necrotic teeth has not yet been determined. Therefore, the aim of this report was to present a case of pulp revascularisation in a severely intruded immature maxillary right incisor.
Case Report: After clinical and radiographic examination, the incisor was defined as necrotic. Revascularisation therapy was performed over multiple appointments. After 21 months of recall appointments, healing of the periapical area and apical closure were seen to be complete. However, at the 27-month appointment, the vitality tests were negative and revascularisation of the right incisor, which had intrusion injuries, had not occurred. The tooth underwent root canal treatment. Finally, the tooth spontaneously erupted into the vestibule and was repositioned with orthodontic appliances.
Conclusion: Although revascularisation can promote continued root development and root dentin apposition, long-term root canal treatment may be required due to treatment results with periapical inflammation in intruded teeth with open apices.
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Plant Dis
January 2025
Hainan University School of Tropical Agriculture and Forestry, Haikou, Hainan, China;
Katsumada galangal seed ( K. Schum) is an important member of the Zingiberaceae family, with both medicinal value and culinary applications (Park et al. 2020).
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December 2024
Division of Neonatology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
L-citrulline (L-CIT), a precursor to L-arginine (L-ARG), is a key contributor to the nitric oxide (NO) signaling pathway. Endothelial dysfunction, characterized by deficient nitric oxide synthesis, is implicated in the pathogenesis of various neonatal conditions such as necrotizing enterocolitis (NEC) and bronchopulmonary dysplasia (BPD) associated pulmonary hypertension (PH). This review summarizes the current evidence around the possible role of L-CIT supplementation in the treatment of these conditions.
View Article and Find Full Text PDFJBRA Assist Reprod
January 2025
Department of Anatomical Sciences, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran.
Objective: Many cancer survivors may experience irreversible infertility due to chemotherapy treatment for childhood cancer. In this study, spermatogenesis development was evaluated following the grafting of fresh and frozen-thawed testicular tissue from neonatal mice to the epididymal fat of adult mice.
Methods: After bilateral castration of recipient mice, fresh or frozen-thawed neonatal testis tissues were grafted into the epididymal fat of the mice.
J Med Virol
January 2025
Department of Infection Biology, Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Kaposi's sarcoma-associated herpesvirus (KSHV) employs diverse mechanisms to subvert host immune responses, contributing to its infection and pathogenicity. As an immune evasion strategy, KSHV encodes the Membrane-Associated RING-CH (MARCH)-family E3 ligases, K3, and K5, which target and remove several immune regulators from the cell surface. In this study, we investigate the impact of K3 and K5 on lymphotoxin receptor (LTβR) ligands, LTβ and LIGHT, which are type II transmembrane proteins and function as pivotal immune mediators during virus infection.
View Article and Find Full Text PDFNarra J
December 2024
Department of Pediatric, Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia.
Sepsis is a systemic infection that significantly causes morbidity and mortality among neonates, which is associated with immature immune response. Variations in the tumor necrosis factor-alpha gene () -308G/A may be linked to neonatal sepsis mortality by modulating interleukins (ILs) involved in the immune response cascade, such as IL-6. The aim of this study was to investigate the association between -308G/A gene variation and IL-6 level with mortality of neonatal sepsis.
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