AI Article Synopsis
- Calcium supplements are commonly used in the U.S. to maintain bone health, raising concerns about potential increased cardiovascular disease (CVD) risks, especially in individuals with type 2 diabetes (T2D).
- A study analyzed the relationship between calcium intake and subclinical CVD measures and mortality in T2D patients, finding no significant links between calcium and calcified plaque or increased mortality.
- Interestingly, the study indicated that calcium supplement use might actually be associated with a reduced risk of all-cause mortality in women with T2D.
Article Abstract
Background: The use of calcium supplements to prevent declines in bone mineral density and fractures is widespread in the United States, and thus reports of elevated cardiovascular disease (CVD) risk in users of calcium supplements are a major public health concern. Any elevation in CVD risk with calcium supplement use would be of particular concern in individuals with type 2 diabetes (T2D) because of increased risks of CVD and fractures observed in this population.
Objective: In this study, we examined associations between calcium intake from diet and supplements and measures of subclinical CVD (calcified plaque in the coronary artery, carotid artery, and abdominal aorta) and mortality in individuals affected by T2D.
Design: We performed a cross-sectional analysis in individuals affected by T2D from the family-based Diabetes Heart Study (n = 720).
Results: We observed no significant associations of calcium from diet or supplements with any of our measures of calcified plaque, and no greater mortality risk was observed with increased calcium intake. Instead, calcium supplement use was modestly associated with reduced all-cause mortality in women (HR: 0.62; 95% CI: 0.42, 0.92; P = 0.017).
Conclusion: Our results do not support a substantial association between calcium intake from diet or supplements and CVD risk in individuals with T2D.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163793 | PMC |
| http://dx.doi.org/10.3945/ajcn.114.090365 | DOI Listing |
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