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DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist. | LitMetric

DLK1-DIO3 represents an imprinted cluster which genes are involved in physiological cell biology as early as the stem cell level and in the pathogenesis of several diseases. Transcription factor-mediated induced pluripotent cells (iPSCs) are considered an unlimited source of patient-specific hematopoietic stem cells for clinical application in patient-tailored regenerative medicine. However, to date there is no marker established able to distinguish embryonic stem cell-equivalent iPSCs or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. This review aims to report the current data on the topic describing both sides of the coin.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11113449PMC
http://dx.doi.org/10.1007/s00018-014-1698-9DOI Listing

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