AI Article Synopsis

  • A study surveyed 21 Mexican hematologists to explore their approaches to diagnosing and treating primary immune thrombocytopenia (ITP) in adults.
  • The majority (66.7%) rely on international guidelines for treatment decisions, while 43% included a numeric threshold for diagnosing ITP (< 100 x 10(9)/l).
  • Treatment practices showed variations from guidelines; most start with prednisone (91%) and many use danazol (41%) for persistent ITP, with 67% recommending splenectomy for second-line treatment.

Article Abstract

In order to identify the clinical approach of a sample of Mexican hematologists for primary immune thrombocytopenia (ITP) in adults in Mexico, we applied an electronic survey via the internet to identify common practices for the diagnosis and treatment of ITP and draw a comparison between the information from these hematologists with international guidelines or the international literature. The results were analyzed using measures of central tendency. The sample was 21 medical hematologists, predominantly from Mexico City (average age: 51.4 years). A total of 66.7% of the surveyed physicians use international guidelines to make therapeutic decisions, and 43% defined ITP including the numerical concept (< 100 x 10(9)/l). We found some differences between requested clinical exams and tests indicated by the guidelines. In first-line treatment (except emergency), 91% of the participants start with prednisone and 24% use dexamethasone. Danazol is used in persistent ITP by most (41%) of the specialists. In second-line treatment, 67% would indicate splenectomy. Some differences were found between clinical practice of the hematologists in Mexico versus guidelines recommendations.

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