AI Article Synopsis
- The blood-brain barrier (BBB) makes it challenging to deliver drugs effectively for brain cancers and neurodegenerative diseases.
- Stem cells, particularly neural stem cells (NSCs) and mesenchymal stem cells (MSCs), offer potential as delivery vehicles since they can cross the BBB and target brain tumors like glioblastoma multiforme (GBM).
- MSCs are considered a safer option than embryonic stem cells, as they do not form tumors and can migrate to areas of injury, making them suitable for clinical trials and potentially available for quick use in treatments.
Article Abstract
The blood brain barrier (BBB) poses a problem to deliver drugs for brain malignancies and neurodegenerative disorders. Stem cells such as neural stem cells (NSCs) and mesenchymal stem cells (MSCs) can be used to delivery drugs or RNA to the brain. This use of methods to bypass the hurdles of delivering drugs across the BBB is particularly important for diseases with poor prognosis such as glioblastoma multiforme (GBM). Stem cell treatment to deliver drugs to neural tumors is currently in clinical trial. This method, albeit in the early phase, could be an advantage because stem cells can cross the BBB into the brain. MSCs are particularly interesting because to date, the experimental and clinical evidence showed 'no alarm signal' with regards to safety. Additionally, MSCs do not form tumors as other more primitive stem cells such as embryonic stem cells. More importantly, MSCs showed pathotropism by migrating to sites of tissue insult. Due to the ability of MSCs to be transplanted across allogeneic barrier, drug-engineered MSCs can be available as off-the-shelf cells for rapid transplantation. This review discusses the advantages and disadvantages of stem cells to deliver prodrugs, genes and RNA to treat neural disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106911 | PMC |
| http://dx.doi.org/10.1186/2001-1326-3-24 | DOI Listing |
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