AI Article Synopsis
- * It involved 75 depressed patients and 75 non-depressed controls, measuring inflammatory cytokines like TNF-α, and depressive symptoms using the BDI-II scale.
- * Results showed that depressed patients had higher levels of TNF-α, and there was a positive correlation between depressive symptoms and TNF-α levels in these patients.
Article Abstract
Objective: The aim of this study was to examine the associations between depression and inflammatory markers in patients admitted to the hospital for myocardial infarction.
Methods: Inflammatory cytokines, including high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) were assessed in a group of 75 depressed participants (score of ≥ 12) and compared to a control group of 75 nondepressed participants (score < 12), all who had been admitted to the hospital for myocardial infarction. The presence of depressive symptoms was assessed using the Beck Depressive Symptoms Inventory II Scale (BDI-II).
Results: Depressed myocardial infarction participants had significantly greater levels of TNF-α (t = 2.070, P < 0.05) compared with control myocardial infarction participants. The BDI-II score was positively correlated with TNF-α levels (r = 0.222, P < 0.05).
Conclusions: These results indicate that the presence of depressive symptoms is positively associated with TNF-α levels among patients who have suffered from myocardial infarction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121679 | PMC |
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