Probabilistic forecasting models describe the aleatory variability of natural systems as well as our epistemic uncertainty about how the systems work. Testing a model against observations exposes ontological errors in the representation of a system and its uncertainties. We clarify several conceptual issues regarding the testing of probabilistic forecasting models for ontological errors: the ambiguity of the aleatory/epistemic dichotomy, the quantification of uncertainties as degrees of belief, the interplay between Bayesian and frequentist methods, and the scientific pathway for capturing predictability. We show that testability of the ontological null hypothesis derives from an experimental concept, external to the model, that identifies collections of data, observed and not yet observed, that are judged to be exchangeable when conditioned on a set of explanatory variables. These conditional exchangeability judgments specify observations with well-defined frequencies. Any model predicting these behaviors can thus be tested for ontological error by frequentist methods; e.g., using P values. In the forecasting problem, prior predictive model checking, rather than posterior predictive checking, is desirable because it provides more severe tests. We illustrate experimental concepts using examples from probabilistic seismic hazard analysis. Severe testing of a model under an appropriate set of experimental concepts is the key to model validation, in which we seek to know whether a model replicates the data-generating process well enough to be sufficiently reliable for some useful purpose, such as long-term seismic forecasting. Pessimistic views of system predictability fail to recognize the power of this methodology in separating predictable behaviors from those that are not.
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http://dx.doi.org/10.1073/pnas.1410183111 | DOI Listing |
PeerJ Comput Sci
July 2024
CINBIO - Biomedical Research Centre, CINBIO, Vigo, Pontevedra, Spain.
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View Article and Find Full Text PDFTeach Learn Med
June 2024
Medical Education Unit, School of Medicine, Western Sydney University, Sydney, Australia.
Pharmacology is a fundamental healthcare discipline, but it can be difficult and counterintuitive for learners to learn. Navigation toward understanding pharmacology can be troublesome, but once the threshold to comprehension is crossed, learners can experience a transformative shift in their ways of thinking and practicing. We conducted an in-depth examination of threshold concepts within pharmacology, aiming to identify and prioritize their learning to improve the medical curriculum and enhance medical treatment and patient safety.
View Article and Find Full Text PDFNaturwissenschaften
February 2024
Telos-Philosophische Praxis, Bürmoos, Austria.
The quasispecies theory is a helpful concept in the explanation of RNA virus evolution and behaviour, with a relevant impact on methods used to fight viral diseases. It has undergone some adaptations to integrate new empirical data, especially the non-deterministic nature of mutagenesis, and the variety of behavioural motifs in cooperation, competition, communication, innovation, integration, and exaptation. Also, the consortial structure of quasispecies with complementary roles of memory genomes of minority populations better fits the empirical data than did the original concept of a master sequence and its mutant spectra.
View Article and Find Full Text PDFJ Intell
November 2023
Dipartimento di Studi UManistici e del Patrimonio Culturale, University of Udine, 33100 Udine, Italy.
This article explores the relationship between neurophysiology and phenomenology in the context of ambiguous figures. Divided into three parts, the study investigates new forms of stimulus and experience errors that arise from ambiguous figures. Part 1 discusses the limitations of a single-disciplinary approach and cautions against relying only on neurophysiological explanations for perceptions.
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