AI Article Synopsis
- A meta-analysis was conducted to examine the relationship between MTLRP genetic polymorphism and type 2 diabetes, which had previously yielded conflicting results.
- Nine case-control studies involving 4460 type 2 diabetes patients and 4114 healthy controls were analyzed, revealing no overall association between MTLRP polymorphism and diabetes risk.
- However, subgroup analyses showed a significant association in Caucasian individuals, indicating a possible link between the MTLRP polymorphism and type 2 diabetes in this demographic.
Article Abstract
Background: Previous studies reported the relation between MTLRP genetic polymorphism and type 2 diabetes, however, the conclusion were conflicting. In the present study, we performed a meta-analysis to reveal this association.
Methods: Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the RevMan 5.0 guidelines. In the meta-analysis, we utilized random-effect model or fixed-effect model to pool the Odds ratio (OR) according to the test of heterogeneity.
Results: A total of nine case-control studies included 4460 type 2 diabetes patients and 4114 healthy control subjects were analyzed. We did not found association between the MTLRP polymorphism and type 2 diabetes risk in the overall population (CC vs CA + AA: OR = 1.02; 95% CI: 0.89-1.17, P = 0.77; A vs C: OR = 1.02; 95% CI: 0.84-0.96, P = 0.62). However, in subgroup analyses stratified by ethnicity, we found significant association of MTLRP polymorphism with type 2 diabetes in Caucasians (CC vs CA + AA: OR = 1.27; 95% CI: 1.02-1.57, P = 0.03; A vs C: OR = 0.74, 95% CI: 0.60-0.91, P = 0.005).
Conclusion: The MTLRP polymorphism was associated with type 2 diabetes in Caucasians.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237884 | PMC |
| http://dx.doi.org/10.1186/1476-511X-13-124 | DOI Listing |
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