Unlabelled: Lipoic acid (LA) is a natural antioxidant and possess beneficial effects on oxidative stress parameters in various tissues. The aim of the study was to estimate of influence of LA on free -SH groups and TNF-alpha levels in spleen homogenates in rats during oxidative stress induced by LPS.
Material And Methods: Experiments were performed on Wistar rats devided into 4 groups: group I (control) received 0,9% NaCl; group II --received LA (100 mg/kg); group III received LPS (10 mg/kg); group IV--received LPS (10 mg/kg) and 30 min later received LA at the dose 100 mg/kg.
Results: Administration of LA after LPS-induced oxidative stress resulted in statistically significant increase in the level of -SH groups and decrease in the level of TNF-alpha when compared to the LPS group (p < 0.001).
Conclusion: The early administration of LA after LPS challenge a significant suppressed symptoms of oxidative stress and inflammatory effects LPS, expressed as a increase in -SH groups and decrease in TNF-alpha in the spleen homogenates.
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