AI Article Synopsis
- The study aimed to find the solubility of pulchinenosiden D in various solvents and measure its partition coefficients using a shaking flask method and HPLC analysis.
- The results showed that pulchinenosiden D has higher solubility in methanol (255.89 g/L) and lower solubility in acetonitrile (0.20 g/L), with solubility increasing as the pH of the buffer solution rises.
- The findings suggest that under gastrointestinal conditions, pulchinenosiden D is likely to be well-absorbed despite its low water solubility, indicating that improving its dissolution rate could enhance its bioavailability.
Article Abstract
Objective: To determine the equilibrium solubility of pulchinenosiden D in different solvents and its n-octanol/water partition coefficients.
Method: Combining shaking flask method and high performance liquid chromatography (HPLC) to detect the n-octanol/water partition coefficients of pulchinenosiden D, the equilibrium solubility of pulchinenosiden D in six organic solvents and different pH buffer solution were determined by HPLC analysis.
Result: n-Octanol/water partition coefficients of pulchinenosiden D in different pH were greater than zero, the equilibrium solubility of pulchinenosiden D was increased with increase the pH of the buffer solution. The maximum equilibrium solubility of pulchinenosiden D was 255.89 g x L(-1) in methanol, and minimum equilibrium solubility of pulchinenosiden D was 0.20 g x L(-1) in acetonitrile.
Conclusion: Under gastrointestinal physiological conditions, pulchinenosiden D exists in molecular state and it has good absorption but poor water-solubility, so increasing the dissolution rate of pulchinenosiden D may enhance its bioavailability.
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