Objective: To screen the matrix and permeation enhancer of Duliang Patches.
Methods: Based on L9 (3(4)) orthogonal experimental design, the content of imperatorin of the release rate and transdermal osmolality were regarded as evaluation indexes to optimize the matrix and permeation enhancer of patches suing of Drug dissolution tester and Franz diffusion cell.
Results: The best prescriplion of sustained-release patch of Duliang was: the quality percentage content of the starch, sodium carboxymethyl cellulose, glycerin, azone, propylene glycol and PEG400 was 6%, 2%, 30%, 1%, 15% and 2.5% respectively. The release behavior of sustained-release patches of Duliang tallied with Higuchi equation and the effect of sustained-release was apparent.
Conclusion: The sustained-release patches of Duliang have good property of sustained-release and transdermal in vitro and the stability of patches is also sound while the release in vivo awaits further inspection.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Cellulose Acetate Butyrate-Based In Situ Gel Comprising Doxycycline Hyclate and Metronidazole.
Polymers (Basel)
December 2024
Program of Pharmaceutical Engineering, Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Cellulose acetate butyrate is a biodegradable cellulose ester bioplastic produced from plentiful natural plant-based resources. Solvent-exchange-induced in situ gels are particularly promising for periodontitis therapy, as this dosage form allows for the direct delivery of high concentrations of antimicrobial agents to the localized periodontal pocket. This study developed an in situ gel for periodontitis treatment, incorporating a combination of metronidazole and doxycycline hyclate, with cellulose acetate butyrate serving as the matrix-forming agent.
View Article and Find Full Text PDFAutomation of a modular method (EN 1528) for analysis of GC-amenable pesticides in food of animal origin.
J Chromatogr A
December 2024
Technical University Dresden, Food Chemistry, Bergstraße 66, Dresden D-01069, Germany.
Current manual multi-methods for analysis of pesticides are limited due to their complexity and scope of pesticides, high demand for time and solvent or unsuitability for broad types of food of animal origin. The following research presents a novel automated sample preparation and purification method for various food matrices of animal origin, including milk, raw milk, dairy products, cheese, eggs, fish, fish products, and offal. The Ultra-Turrax® Tube Drive System enables quick fat extraction using a solvent mixture of cyclohexane/ethyl acetate/acetonitrile.
View Article and Find Full Text PDFDegradable Radical Polymer Cathode for Lithium Battery with Long-Term Cycling Capability.
Angew Chem Int Ed Engl
December 2024
Fudan University, Handan Road 220, 200433, Shanghai, CHINA.
Polymer-based organic electrodes for rechargeable batteries are attractive due to their design flexibility, sustainability, and environmental compatibility. Unfortunately, waste management of conventional polymer materials typically involves incineration, which emits greenhouse gases. Consequently, degradable polymers should be ideal candidates for future green batteries.
View Article and Find Full Text PDFSynthesis and Properties of Symmetrical and Asymmetrical Polyferrocenylmethylenes.
Chemistry
December 2024
Saarland University, Faculty of Natural Sciences and Technology, Campus Saarbrücken, 66123, Saarbrücken, GERMANY.
The synthesis of differently substituted polyferrocenylmethylenes (PFM) via ring-opening transmetalation polymerization (ROTP) is reported. A number of novel, symmetrically and asymmetrically substituted carba[1]magnesocenophanes have been prepared, which were used as precursors and allowed investigations of the influence of different substitution patterns on the PFM polymer properties. The novel carba[1]magnesocenophanes have been fully characterized by 1H and 13C NMR spectroscopy, and structurally authenticated by single-crystal X-ray diffraction (SC-XRD).
View Article and Find Full Text PDFOvercoming drug delivery challenges with lipid-based nanofibers for enhanced wound repair.
Biomater Sci
December 2024
Department of Animal Biology, School of Life Sciences, University of Hyderabad, Prof. C.R. Rao Road, Gachibowli, Hyderabad, 500046, Telangana, India.
Wound healing is a dynamic, multi-phase process that includes haemostasis, tissue regeneration, cellular proliferation, and matrix modification. Traditional wound care procedures frequently encounter complications such as delayed healing and infection, demanding new therapeutic approaches. In this context, nanomaterial-based devices provide considerable benefits due to their capacity to improve medication delivery and tissue healing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!