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| http://dx.doi.org/10.3201/eid2007.ac2007 | DOI Listing |
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Modeling Lymphoma Angiogenesis, Lymphangiogenesis, and Vessel Co-Option, and the Effects of Inhibition of Lymphoma-Vessel Interactions with an αCD20-EndoP125A Antibody Fusion Protein.
Cells
November 2024
Division of Hematology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Lymphoma growth, progression, and dissemination require tumor cell interaction with supporting vessels and are facilitated through tumor-promoted angiogenesis, lymphangiogenesis, and/or lymphoma vessel co-option. Vessel co-option has been shown to be responsible for tumor initiation, metastasis, and resistance to anti-angiogenic treatment but is largely uncharacterized in the setting of lymphoma. We developed an in vitro model to study lymphoma-vessel interactions and found that mantle cell lymphoma (MCL) cells co-cultured on Matrigel with human umbilical vein (HUVEC) or human lymphatic (HLEC) endothelial cells migrate to and anneal with newly formed capillary-like (CLS) or lymphatic-like (LLS) structures, consistent with lymphoma-vessel co-option.
View Article and Find Full Text PDFA Contemporary Picture of Coagulase-Negative Staphylococcal Endocarditis: A Nationwide GAMES Cohort Study.
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October 2024
Hospital Clínic de Barcelona, IDIBAPS, Universitat de Barcelona, Barcelona, Spain; CIBER de Enfermedades Infecciosas-CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:
Background: Coagulase-negative staphylococci (CoNS) are an increasingly common cause of infective endocarditis (IE) and lack recent data from large studies.
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Prognostic value of germline mutations in metastatic hormone-sensitive prostate cancer (mHSPC).
Urol Oncol
October 2024
Medical Oncology, Hospital Universitario De Torrejón, Madrid, Spain; Faculty of Medicine, Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain. Electronic address:
Background: About 8% to 12% of patients presenting with mHSPC exhibit germline pathogenic variants (PV) in cancer predisposition genes. The aim of this study is to assess the presence of germline PV as a prognostic factor in the setting of mHSPC and to determine whether mutational status can predict rapid progression to castration resistance.
Methods: Genetic analysis using a multigene next-generation sequencing (NGS) panel was performed on 34 patients diagnosed with mHSPC undergoing treatment.
Recent Advances and Future Prospects for Memristive Materials, Devices, and Systems.
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Department of Mechanical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139, United States.
Memristive technology has been rapidly emerging as a potential alternative to traditional CMOS technology, which is facing fundamental limitations in its development. Since oxide-based resistive switches were demonstrated as memristors in 2008, memristive devices have garnered significant attention due to their biomimetic memory properties, which promise to significantly improve power consumption in computing applications. Here, we provide a comprehensive overview of recent advances in memristive technology, including memristive devices, theory, algorithms, architectures, and systems.
View Article and Find Full Text PDFElectrical resistivity tomography (ERT) and geochemical analysis dataset to delimit subsurface affected areas by livestock pig slurry ponds.
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Sustainable Use, Management, and Reclamation of Soil and Water Research Group, Escuela Técnica Superior de Ingeniería Agronómica, Universidad Politécnica de Cartagena, Paseo Alfonso XIII, 52, 30203 Cartagena, Spain.
The electrical resistivity tomography (ERT) technique was employed with the support of geochemical analyses to delimit the affected surface area by slurry pig ponds. Data were taken in three selected slurry ponds located in Fuente Álamo municipality, Murcia region (SE Spain), to obtain electrical resistivity value-based 2D sections and 3D blocks. All ERT-based survey data were obtained in September 2020 using a SuperSting R8 resistivity meter from Advanced Geosciences Inc.
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