Updated French guidelines for clinical practice have been published by the National Cancer Institute in 2010, concerning the diagnosis and the treatment of cervix and endometrial cancers. The diagnosis of cervix cancer, suspected when a cervix tumour is observed in a patient presenting with vaginal bleeding, especially in women with risk factors (previous cervix dysplasia, HIV infection, tobacco use). The diagnosis is confirmed by pathology of cervix biopsy (macroscopic cervix tumour or microscopic lesions detected by screening). The diagnosis of endometrial cancer should be evoked in post-menopausal women presenting with vaginal bleeding, especially in high risk populations (obese, long exposure to estrogens). The diagnosis is based on histologic examination of endometrial biopsy. The assessment of pelvic extension must include clinical examination and pelvic and lombo-aortic MRI imaging.
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Front Public Health
January 2025
Department of Pathology, West China Second University Hospital, Sichuan University, Chengdu, China.
Background: Understanding the HPV genotype distribution in invasive cervical cancer (ICC) is essential for vaccine optimization. This study presents a comprehensive analysis of HPV genotypes in ICC tissues from patients in western China, with the aim of informing regional vaccine policy and prevention strategies.
Methods: DNA was extracted from 1,908 paraffin-embedded ICC samples, and 23 HPV genotypes were detected via PCR and reverse dot hybridization gene chip assays.
J Transl Med
December 2024
Tongji Medical College, Maternal and Child Health Hospital of Hubei Province, Huazhong University of Science and Technology, Wuhan, Hubei Province, 430070, China.
Background: As a prevalent and deadly malignant tumor, the treatment outcomes for late-stage patients with cervical squamous cell carcinoma (CSCC) are often suboptimal. Previous studies have shown that tumor progression is closely related with tumor metabolism and microenvironment reshaping, with disruptions in energy metabolism playing a critical role in this process. To delve deeper into the understanding of CSCC development, our research focused on analyzing the tumor microenvironment and metabolic characteristics across different regions of tumor tissue.
View Article and Find Full Text PDFCancer Med
January 2025
Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, People's Republic of China.
Objective: To explore the risk factors associated with the pathological progression to invasive carcinoma following the conization of cervical high-grade squamous intraepithelial lesions (HSIL) and to construct a risk prediction model to guide preoperative risk assessment and optimize the selection of surgical approaches.
Methods: A retrospective analysis was conducted on the clinical data of 3337 patients who underwent cervical conization for HSIL at Hunan Provincial Maternal and Child Health Care Hospital from December 2016 to March 2022. The patients were categorized into the pathological progression group (398 cases) and the nonprogression group (2939 cases) based on postconization pathology results.
PLoS One
December 2024
Department of Pharmacy, Huaihe Hospital, Henan University, Henan, China.
Background: The prophylactic vaccines available to protect against infections by human papillomavirus (HPV) are well tolerated and highly immunogenic. This systematic review and meta-analysis aimed to explore the efficacy of HPV vaccination on the risk of HPV infection and recurrent diseases related to HPV infection in individuals undergoing local surgical treatment.
Methods: A literature search was performed using PubMed/MEDLINE, Embase, the Cochrane Library, Scopus, Web of Science, and bioRxiv/medRxiv from inception to July 15, 2024.
PLoS One
December 2024
Faculty of Health Sciences, Department of Medicine & CIDRI-Africa, Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.
Background: Cervical cancer is the second most common cancer in women in South Africa. Infection with high-risk types of human papillomavirus (HPV) is the cause of cervical cancer, which can be prevented by HPV vaccination. However, there is wide variation in HPV vaccination coverage among the urban districts of South Africa; with the lowest coverage being 40% in eThekwini, KwaZulu-Natal.
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