Ptychographic techniques are currently the subject of increasing scientific interest due to their capability to retrieve the complex transmission function of an object at very high resolution. However, they impose a substantial burden in terms of acquisition time and dimension of the scanned area, which limits the range of samples that can be studied. We have developed a new method that combines the ptychographic approach in one direction with Fresnel propagation in the other by employing a strongly asymmetric probe. This enables scanning the sample in one direction only, substantially reducing exposure times while covering a large field of view. This approach sacrifices ptychographic-related resolution in one direction, but removes any limitation on the probe dimension in the direction orthogonal to the scanning, enabling the scan of relatively large objects without compromising exposure times.
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http://dx.doi.org/10.1364/OE.22.017281 | DOI Listing |
J Occup Environ Hyg
January 2025
Institute of Physical Factors and Occupational Health, Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, Guangdong Province, China.
The noise exposure levels of workers wearing hearing protective devices (HPDs) depend on ambient noise and the protective effect of hearing protectors. This cross-sectional study aimed to adjust for cumulative noise exposure (CNE) based on the effective protection of hearing protection devices and explore the dose-response relationship between noise-induced hearing loss (NIHL) and adjusted cumulative noise exposure. A questionnaire was used to acquire the basic characteristics and occupational information of noise-exposed workers.
View Article and Find Full Text PDFHepatology
January 2025
Department of Medicine, Internal Medicine Residency Program, Baylor College of Medicine, Houston, Texas, USA.
Background: Severe alcohol-associated hepatitis (AH) is rising in incidence with a high mortality burden. While corticosteroids are recommended for eligible patients with severe AH, no guidance exists for the timing of steroid initiation, tapering regimens, and surveillance of adverse events.
Objective: We aim to systematically review these variables and provide evidence-based recommendations for the inpatient and outpatient management of severe AH.
PLoS One
January 2025
Department of Environmental Health, Qingdao Municipal Center for Disease Control and Prevention, Qingdao Institute of Disease Prevention, Qingdao, Shandong, China.
Background: It is crucial to comprehend the interplay between air pollution and meteorological conditions in relation to population health within the framework of "dual-carbon" targets. The purpose of this study was to investigate the impact of intricate environmental factors, encompassing both meteorological conditions and atmospheric pollutants, on respiratory disease (RD) mortality in Qingdao, a representative coastal city in China.
Methods: The RD mortality cases were collected from the Chronic Disease Surveillance Monitoring System in Qingdao during Jan 1st, 2014 and Dec 31st, 2020.
Biochemistry
January 2025
BHF Centre of Research Excellence, School of Medicine and Life Sciences, King's College London, London SE1 9NH, United Kingdom.
Transmembrane glucose transport, facilitated by glucose transporters (GLUTs), is commonly understood through the simple mobile carrier model (SMCM), which suggests that the central binding site alternates exposure between the inside and outside of the cell, facilitating glucose exchange. An alternative "multisite model" posits that glucose transport is a stochastic diffusion process between ligand-operated gates within the transporter's central channel. This study aims to test these models by conducting atomistic molecular dynamics simulations of multiple glucose molecules docked along the central cleft of GLUT1 at temperatures both above and below the lipid bilayer melting point.
View Article and Find Full Text PDFDNA Cell Biol
January 2025
Department of Anesthesiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China.
Lung cancer represents a significant global health burden, with non-small cell lung cancer (NSCLC) being the most common subtype. The current standard of care for NSCLC has limited efficacy, highlighting the necessity for innovative treatment options. Lidocaine, traditionally recognized as a local anesthetic, has emerged as a compound with potential antitumor and anti-inflammatory capabilities.
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