We postulate that phenotypic resistance to antibiotics, persistence, is not an evolved (selected-for) character but rather like mutation, an inadvertent product of different kinds of errors and glitches. The rate of generation of these errors is augmented by exposure to these drugs. The genes that have been identified as contributing to the production of persisters are analogous to the so-called mutator genes; they modulate the rate at which these errors occur and/or are corrected. In theory, these phenotypically resistant bacteria can retard the rate of microbiological cure by antibiotic treatment.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4253300 | PMC |
| http://dx.doi.org/10.1016/j.mib.2014.06.016 | DOI Listing |
Publication Analysis
Top Keywords
resistance antibiotics
8
persistence copacetic
4
copacetic parsimonious
4
parsimonious hypothesis
4
hypothesis existence
4
existence non-inherited
4
non-inherited resistance
4
antibiotics postulate
4
postulate phenotypic
4
phenotypic resistance
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!