AI Article Synopsis
- * Despite their therapeutic potential, there has been limited research focused on improving their synthetic chemistry.
- * This review summarizes existing biological studies and available synthesis methods for α-hydroxytropolones, aiming to inspire further research and new synthetic strategies in this area.
Article Abstract
α-Hydroxytropolones are a subclass of the troponoid family of natural products that are of high interest due to their broad biological activity and potential as treatment options for several diseases. Despite this promise, there have been scarce synthetic chemistry-driven optimization studies on the molecules. The following review highlights key developments in the biological studies conducted on α-hydroxytropolones to date, including the few synthetic chemistry-driven optimization studies. In addition, we provide an overview of the methods currently available to access these molecules. This review is intended to serve as a resource for those interested in biological activity of α-hydroxytropolones, and inspire the development of new synthetic methods and strategies that could aid in this pursuit.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114738 | PMC |
| http://dx.doi.org/10.1039/C4MD00055B | DOI Listing |
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