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Heterogeneity of Apolipoprotein B Levels Among Hispanic or Latino Individuals Residing in the US.
JAMA Cardiol
January 2025
Cardiology Division, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
Article Synopsis
- The study focuses on understanding apolipoprotein B (apoB) levels in the Hispanic/Latino community and their relationship to cardiovascular disease risk.
- Participants were part of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), which included a diverse range of individuals across four major US cities.
- Results indicated that the average apoB concentration was higher in males compared to females, highlighting potential gender differences in cardiovascular risk among Hispanic or Latino populations.
Contribution of large genomic rearrangements in BRCA1/2 genes and CHEK2 1100delC allele variant to the development of breast/ovarian cancer in Argentinian population.
Breast Cancer Res Treat
December 2024
Centro Nacional de Genética Médica, ANLIS ''Dr Carlos G Malbrán'', Ministerio de Salud de La Nación, Buenos Aires, Argentina.
Purpose: Among women in Argentina, the most common cancer is breast cancer (BC) with 21,631 new cases and 6436 deaths per year. The ovarian cancer (OC) is fifteenth in frequency. The contribution of cancer-related large genomic rearrangements (LGRs) of the BRCA1/BRCA2 genes and the 1100delC allelic variant in the CHEK2 gene has not yet been widely studied in our population.
View Article and Find Full Text PDFThe Chilean COVID-19 Genomics Network Biorepository: A Resource for Multi-Omics Studies of COVID-19 and Long COVID in a Latin American Population.
Genes (Basel)
October 2024
Department of Anatomic Pathology, Faculty of Medicine, University of Chile, Santiago 8380453, Chile.
Although a lack of diversity in genetic studies is an acknowledged obstacle for personalized medicine and precision public health, Latin American populations remain particularly understudied despite their heterogeneity and mixed ancestry. This gap extends to COVID-19 despite its variability in susceptibility and clinical course, where ethnic background appears to influence disease severity, with non-Europeans facing higher hospitalization rates. In addition, access to high-quality samples and data is a critical issue for personalized and precision medicine, and it has become clear that the solution lies in biobanks.
View Article and Find Full Text PDFEmergence of Elizabethkingia miricola in the Brazilian Amazon region.
Sci Total Environ
October 2023
Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil. Electronic address:
Article Synopsis
- Infectious diseases like Elizabethkingia miricola pose significant risks not just to humans and animals, but to entire ecosystems, highlighting the importance of the One Health approach.
- An emerging strain of E. miricola in Brazil has shown nearly untreatable antibiotic resistance and is linked to increased anuran (frog) mortality, indicating a troubling trend in wildlife health.
- Genomic studies show this resistant strain (EM15) is closely related to others found globally, emphasizing its potential threat to public and environmental health in biodiverse regions like the Amazon.
Prevalence of single-nucleotide variants in twenty-five pharmacogenes from a Cuban sample cohort.
Front Pharmacol
September 2024
Laboratory of Pharmacology, Department of Pharmacology, Institute of Marine Sciences (ICIMAR), Havana, Cuba.
Introduction: The Cuban population is genetically diverse, and information on the prevalence of genetic variants is still limited. As complex admixture processes have occurred, we hypothesized that the frequency of pharmacogenetic variants and drug responses may vary within the country. The aims of the study were to describe the frequency distribution of 43 single-nucleotide variants (SNVs) from 25 genes of pharmacogenetic interest within the Cuba population and in relation to other populations, while taking into consideration some descriptive variables such as place of birth and skin color.
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