A lump in the scrotum is a common presentation in most surgical clinics. However, myoepithelial tumours may not be up on the list of differentials. Although they may look benign, myoepithelial tumours are rare and have malignant potential. Treatment of these tumours involved total excision and adequate follow-up in cases of malignancy. These groups of tumours have not been reported in the scrotum in the past, but their occurrence in the vagina may not come as a surprise bearing in mind the embryonic origin of both organs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118141 | PMC |
| http://dx.doi.org/10.1093/jscr/rju064 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
S100-positive stroma in salivary gland basal cell adenomas: a neoplastic component with CTNNB1 mutations.
Virchows Arch
December 2024
Division of Translational Oncoimmunology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Basal cell adenomas (BCAs) are benign epithelial tumors of the salivary gland, characterized by the proliferation of basaloid and luminal cells. In addition, a distinctive spindle cell stroma, that is immunohistochemically-positive for S100, is often observed in BCAs. Based on the ultrastructural findings, the S100-positive stroma was presumed to originate from neoplastic myoepithelial cells.
View Article and Find Full Text PDFA hybrid epithelial-mesenchymal transition program enables basal epithelial cells to bypass stress-induced stasis and contributes to a metaplastic breast cancer progenitor state.
Breast Cancer Res
December 2024
Department of Pathology, University of California, San Francisco, San Francisco, CA, 94143, USA.
Background: Human mammary epithelial cell (HMEC) cultures encounter a stress-associated barrier termed stasis, during which most cells adopt a senescence-like phenotype. From these cultures, rare variants emerge from the basal epithelial population, re-initiating growth. Variants exhibit pre-malignant properties, including an aberrant epigenetic program that enables continued proliferation and acquisition of genetic changes.
View Article and Find Full Text PDFDifferential somatic coding variant landscapes between laser microdissected luminal epithelial cells from canine mammary invasive ductal solid carcinoma and comedocarcinoma.
BMC Cancer
December 2024
Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Background: Breast cancer (BC) is the most common cancer in women. Likewise, canine mammary tumors (CMT) represent the most common cancer in intact female dogs and develop in the majority spontaneously. Similarities exist in clinical presentation, histopathology, biomarkers, and treatment.
View Article and Find Full Text PDFImmunocytochemistry of myoepithelial cell types in canine mammary tumors.
Biotech Histochem
December 2024
Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.
Myoepithelial cells (MECs) are known to play an active role in mixed mammary tumors and are found in dogs as well as in humans. The study aimed to assess the morphologic features of epithelial and mesenchymal cells and MECs and investigate their roles in epithelial-mesenchymal transformation in different tumor types in canine mammary tumors. Immunohistochemical staining was performed on 165 specimens from benign mixed tumors (BMT), carcinosarcomas, and simple carcinomas (SC).
View Article and Find Full Text PDFClear cell myoepithelioma of palate: A rare case report with brief review of literature.
J Oral Maxillofac Pathol
October 2024
Department of Pathology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y.Patil Vidyapeeth, Pune, Maharashtra, India.
Myoepitheliomas are very rare salivary gland neoplasms seen mainly in the major salivary glands (~40%) followed by minor salivary glands (~21%). Palatal myoepitheliomas are rare, with clear cell types being even rarer. Due to the rarity of this tumor, it lacks specific features that are diagnostic in cytology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!