Domiciliary long-term non-invasive ventilation in COPD: should we select subgroups with a better likelihood to respond to NIV in subsequent randomised controlled trials?

Thorax

Univ Grenoble Alpes, HP2 INSERM U1042, Grenoble, France Clinique Universitaire de Physiologie et Sommeil, Pôle Thorax et Vaisseaux, Grenoble University Hospital, Grenoble, France.

Published: December 2014

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Source
http://dx.doi.org/10.1136/thoraxjnl-2014-205949DOI Listing

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Article Synopsis
  • Chronic obstructive pulmonary disease (COPD) patients often require long-term non-invasive ventilation (NIV), but there's uncertainty around existing guidelines; this study examines health patterns before initiating home NIV and compares mortality outcomes among different patient groups based on their pre-NIV health.
  • Analyzing data from over 54,000 individuals with COPD between 2015 and 2019, researchers identified four distinct health trajectories, with varying initiation circumstances, comorbidities, and outcomes; notable differences in mortality were observed among the clusters.
  • The findings highlight the need for improved understanding of these health patterns to address inconsistencies in NIV use and ultimately personalize treatment for COPD patients.
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