AI Article Synopsis
- A novel type of squalene conjugates was developed, linking drugs like paclitaxel and camptothecin with a design that allows them to self-assemble in water.
- The compounds are connected by a disulfide linker that enables drug release inside cells, showing effective in vitro performance.
- The paclitaxel-squalene derivative maintains similar effectiveness to free paclitaxel and successfully enters A549 cancer cells, highlighting potential for new squalene-based drug delivery systems.
Article Abstract
The present study reports the preparation of a novel class of squalene conjugates with paclitaxel, podophyllotoxin, camptothecin and epothilone A. The obtained compounds are characterized by a squalene tail that makes them able to self-assemble in water, and by a drug unit connected via a disulfide-containing linker to secure the release inside the cell. All the obtained compounds were effectively able to self-assemble and to release the parent drug in vitro. Disulfide-containing paclitaxel-squalene derivative showed a similar biological activity when compared to the free drug. Immunofluorescence assay shows that this squalene conjugate enters A549 cells and stain microtubule bundles. The results described herein pave the way for different classes of squalene-based releasable nanoassemblies.
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| http://dx.doi.org/10.1016/j.ejmech.2014.07.035 | DOI Listing |
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New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.
Eur J Med Chem
October 2014
Dipartimento di Chimica, Università degli Studi di Milano, Via C. Golgi 19, 20133 Milano, Italy. Electronic address:
Article Synopsis
- A novel type of squalene conjugates was developed, linking drugs like paclitaxel and camptothecin with a design that allows them to self-assemble in water.
- The compounds are connected by a disulfide linker that enables drug release inside cells, showing effective in vitro performance.
- The paclitaxel-squalene derivative maintains similar effectiveness to free paclitaxel and successfully enters A549 cancer cells, highlighting potential for new squalene-based drug delivery systems.
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