Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes.

Lidia Robert Christina Harview Ryan Emerson Xiaoyan Wang Stephen Mok Blanca Homet Begonya Comin-Anduix Richard C Koya Harlan Robins Paul C Tumeh Antoni Ribas

Oncoimmunology

Department of Medicine (Division of Hematology-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA ; Department of Surgery (Division of Surgical-Oncology); University of California Los Angeles (UCLA); Los Angeles, CA USA ; Jonsson Comprehensive Cancer Center (JCCC); University of California Los Angeles (UCLA); Los Angeles, CA USA.

Published: February 2021

Targeting immune inhibitory receptors has brought excitement, innovation and hope to cancer patients. Our recent work revealed the immunological effects of blocking the CTLA4 and PD-1 immune checkpoints on T cell receptor usage among peripheral blood cells, and further uncovers how the expansion of the T cell repertoire matches the immunotoxicity profile of the therapy.

Download full-text PDF	Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108466	PMC
http://dx.doi.org/10.4161/onci.29244	DOI Listing

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