Aim: To determine the influence of eversion endarterectomy on circulating adhesion molecules (CAMs): E-selectin, intercellular circulating adhesion molecule-1 (ICAM-1) and vascular circulating adhesion molecule-1 (VCAM-1).
Methods: Forty patients underwent carotid endarterectomy. Venous blood samples have been gathered before operation, one hour and six hours after the operation and three months after the procedure. Levels of CAMs have been determined by sandwich ELISA test.
Results: Statistically significant decrease of the ICAM-1 levels one hour and six hours after the endarterectomy compared to levels before the operation have been found. There were no statistically significant changes in concentration of VCAM-1 and E-selectin. Three months after the operation levels of CAMs where similar to those before the operation. There was a statistically significant decrease of systolic arterial blood pressure levels within early postoperative period.
Conclusion: Results suggest that decrease of ICAM-1 could be a possible marker of endothelial de-activation after plaque removal. Endarterectomy has a positive influence on systolic arterial blood pressure in early postoperative period. Further investigations are necessary to better understand and prevent the development of atherosclerotic plaque.
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