AI Article Synopsis
- Researchers surveyed the chemical constituents of Abies nukiangensis, discovering seven new compounds: six triterpenes and one phenol, along with 37 known ones.
- The structures of the new compounds were determined using 1D and 2D NMR analysis and HRMS data, with absolute configurations confirmed through X-ray crystallography.
- Some of the new compounds, specifically compounds 3 and 8-10, exhibited significant anti-hepatitis C virus activity, with effective concentration (EC50) values ranging from 1.33 to 3.73 μM.
Article Abstract
During a survey on chemical constituents of Abies nukiangensis, seven previously unreported compounds, including six triterpenes (1-6) and one phenol (7) were isolated and characterized, together with 37 known miscellaneous chemical constituents. The structures of compounds 1-7 were established mainly by extensive analysis of the 1D and 2D NMR, as well as HRMS data. The absolute configurations of compounds 1 and 8 were confirmed unambiguously by the Cu-Kα X-ray crystallography. Compounds 3 and 8-10 showed significant anti-hepatitis C virus effects with EC50 values of 3.73, 2.67, 1.33 and 2.25μM, respectively.
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| http://dx.doi.org/10.1016/j.phytochem.2014.07.003 | DOI Listing |
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