Anticancer effects of chitin and chitosan derivatives.

Adv Food Nutr Res

Department of Marine-bio Convergence Science, Specialized Graduate School Science and Technology Convergence, Marine Bioprocess Research Center, Pukyong National University, Busan, South Korea. Electronic address:

Published: December 2014

Despite considerable progress in medical research, cancer is still one of the high-ranking causes of death in the world. It is the second most common cause of death due to disease after heart disease, and according to World Health Organization it will be the cause of death for more than 10 million people in 2020; therefore, one of the main research goals for researchers investigating new anticancer agents. But the major complication for the cancer cure without surgeries is side effects. Especially, cytotoxic anticancer chemotherapeutic agents generally produce severe side effects, while reducing host resistance to cancer and infections. Therefore, it is important to find new, powerful anticancer agents that are highly effective, biodegradable, and biocompatible. Chitin and chitosan are biopolymers which have unique structural possibilities for chemical and mechanical modifications to generate novel properties, functions. These biopolymers are biocompatible, biodegradable, and nontoxic, and their chemical properties allow them to be easily processed into gels, sponges, membranes, beads, and scaffolds forms also. Due to their unique properties, they are excellent candidates for cancer cure or cancer diagnosis.

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-800269-8.00012-9DOI Listing

Publication Analysis

Top Keywords

chitin chitosan
8
anticancer agents
8
cancer cure
8
side effects
8
cancer
5
anticancer
4
anticancer effects
4
effects chitin
4
chitosan derivatives
4
derivatives despite
4

Similar Publications

Holocellulose from a Winemaking By-Product to Develop a Biopolymeric System for Bacterial Immobilization: Adsorption of Ochratoxin A in Wine Model Solutions (Box-Behnken Design).

Toxins (Basel)

January 2025

Multidisciplinary Agroindustry Research Laboratory, Carrera de Ingeniería en Construcción, Instituto de Ciencias Químicas Aplicadas, Universidad Autónoma de Chile, Talca 3460000, Chile.

Significant agro-industrial waste is produced during the winemaking process, including grape stalks, which are a rich source of the valuable biopolymer holocellulose that can be utilized for biotechnological processes. The purpose of this study was to delignify grape stalks in order to extract holocellulose. Then Lactobacillus plantarum (LP) was immobilized in the interstitial spaces of holocellulose and then coated with natural polymers (chitosan, Ch; and alginate, Al) to create the Holo-LP/Ch/Al complex.

View Article and Find Full Text PDF

Chitosan, a multifaceted amino polysaccharide biopolymer derived from chitin, has extensive antibacterial efficacy against diverse pathogenic microorganisms, including both Gram-negative and Gram-positive bacteria, in addition to fungi. Over the course of the last several decades, chitosan nanoparticles (NPs), which are polymeric and bio-based, have garnered a great deal of interest as efficient antibacterial agents. This is mostly due to the fact that they are used in a wide variety of applications, including medical treatments, food, chemicals, and agricultural products.

View Article and Find Full Text PDF

Protective Effects of Chitosan Oligosaccharide Against Lipopolysaccharide-Induced Inflammatory Response and Oxidative Stress in Bovine Mammary Epithelial Cells.

Mar Drugs

January 2025

The Key Laboratory of Animal Genetic Resource and Breeding Innovation, College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524088, China.

Chitosan oligosaccharide (COS) is receiving increasing attention as a feed additive in animal production. COS has a variety of biological functions, including anti-inflammatory and antioxidant activities. Mastitis is a major disease in dairy cows that has a significant impact on animal welfare and production.

View Article and Find Full Text PDF

In this study, we prepared a new multi-functional intelligent hydrogel preservation film using soy hull nanocellulose (SHNC), polyvinyl alcohol (PVA), chitosan (CS), and anthocyanin (Anth) as raw materials. The physicochemicals of the hydrogel preservation film, and its role in monitoring the freshness and freshness of salmon was evaluated. The results showed that the monomers were crosslinked by hydrogen, ester bonds, and electrostatic interactions in the hydrogel film, and there were three-dimensional pores in the hydrogel film.

View Article and Find Full Text PDF

In this study, octenyl succinic acid sodium starch (OSAS) decorated with chitosan (CS) of different molecular weights (50-150 kDa) and concentrations (10-30 mg/mL) was used to stabilize an emulsion coencapsulating with vitamin A (V) and vitamin D (V). The effect of CS decoration on the thermal and UV stability of the emulsion, as well as the underlying mechanism, was elucidated. The incorporation of CS increased the retention rates of V and V by 11.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!