AI Article Synopsis
- The study investigates whether hematopoietic progenitor cells in the embryonic yolk sac are responsible for forming the first platelets.
- It finds that while megakaryocyte (MK) colony-forming cells from embryonic day 8.5 can make polyploid MKs, they do not generate the initial platelet-forming cells.
- Instead, the research reveals that proplatelet formation arises from a distinct lineage of diploid cells in the yolk sac, independent of the conventional progenitor cell lineage.
Article Abstract
In this study, we test the assumption that the hematopoietic progenitor/colony-forming cells of the embryonic yolk sac (YS), which are endowed with megakaryocytic potential, differentiate into the first platelet-forming cells in vivo. We demonstrate that from embryonic day (E) 8.5 all megakaryocyte (MK) colony-forming cells belong to the conventional hematopoietic progenitor cell (HPC) compartment. Although these cells are indeed capable of generating polyploid MKs, they are not the source of the first platelet-forming cells. We show that proplatelet formation first occurs in a unique and previously unrecognized lineage of diploid platelet-forming cells, which develop within the YS in parallel to HPCs but can be specified in the E8.5 Runx1-null embryo despite the absence of the progenitor cell lineage.
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| http://dx.doi.org/10.1182/blood-2014-02-559468 | DOI Listing |
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