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Hydrophobin film structure for HFBI and HFBII and mechanism for accelerated film formation. | LitMetric

AI Article Synopsis

  • Hydrophobins are proteins produced by filamentous fungi that have significant roles in both biology and nanotechnology due to their unique properties at interfaces.
  • The study utilized protein docking, molecular dynamics simulation, and electron cryo-microscopy to explore the structural details of films made from two specific hydrophobins (HFBI and HFBII) from Trichoderma reesei.
  • Results indicate potential alternate structures with different symmetries and unit cell sizes, which could enhance the understanding of hydrophobin films' behavior and their applications in various fields.

Article Abstract

Hydrophobins represent an important group of proteins from both a biological and nanotechnological standpoint. They are the means through which filamentous fungi affect their environment to promote growth, and their properties at interfaces have resulted in numerous applications. In our study we have combined protein docking, molecular dynamics simulation, and electron cryo-microscopy to gain atomistic level insight into the surface structure of films composed of two class II hydrophobins: HFBI and HFBII produced by Trichoderma reesei. Together our results suggest a unit cell composed of six proteins; however, our computational results suggest P6 symmetry, while our experimental results show P3 symmetry with a unit cell size of 56 Å. Our computational results indicate the possibility of an alternate ordering with a three protein unit cell with P3 symmetry and a smaller unit cell size, and we have used a Monte Carlo simulation of a spin model representing the hydrophobin film to show how this alternate metastable structure may play a role in increasing the rate of surface coverage by hydrophobin films, possibly indicating a mechanism of more general significance to both biology and nanotechnology.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117420PMC
http://dx.doi.org/10.1371/journal.pcbi.1003745DOI Listing

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