Purpose: This work intends to demonstrate a new method for quantifying concentration of sodium ( Na) of bi-exponential T relaxation in patients on MRI scanners at 3.0 Tesla.
Theory And Methods: Two single-quantum (SQ) sodium images acquired at very-short and short echo times (TE = 0.5 and 5.0 ms) are subtracted to produce an image of the short-T component of the bi-exponential (or bound) sodium. An integrated calibration on the SQ and short-T images quantifies both total and bound sodium concentrations. Numerical models were used to evaluate signal response of the proposed method to the short-T components. MRI scans on agar phantoms and brain tumor patients were performed to assess accuracy and performance of the proposed method, in comparison with a conventional method of triple-quantum filtering.
Results: A good linear relation (R = 0.98) was attained between the short-T image intensity and concentration of bound sodium. A reduced total scan time of 22 min was achieved under the SAR restriction for human studies in quantifying both total and bound sodium concentrations.
Conclusion: The proposed method is feasible for quantifying bound sodium concentration in routine clinical settings at 3.0 Tesla. Magn Reson Med 74:162-174, 2015. © 2014 Wiley Periodicals, Inc.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312273 | PMC |
| http://dx.doi.org/10.1002/mrm.25393 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
How chloride salt mixtures affect the final gel properties of low-sodium myofibrillar protein: Underlining the perspective of gelation process.
Meat Sci
December 2024
School of Food Science and Engineering, South China University of Technology, Guangzhou 510641, China. Electronic address:
This study aimed to investigate the performance differences of low-sodium myofibrillar protein (MP) gels substituted by different chloride salt mixtures from the perspective of gelation process. The results revealed that low-sodium MP substituted by KCl/CaCl exhibited higher turbidity and particle size at 40 % substitution, and formed protein aggregates earlier at 53 °C. During the gelation process, KCl/CaCl increased the extent of cross-linking as the substitution level increased from 10 % to 40 %, which was prone to forming final gels with poor palatability.
View Article and Find Full Text PDFpH/HO dual-responsive macrophage-targeted chitosaccharides nanoparticles to combat intracellular bacterial infection.
Colloids Surf B Biointerfaces
December 2024
Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Province Key Laboratory of Biomedical Materials and Chemical Measurement, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, PR China. Electronic address:
Antibiotic resistance combined with bacteria internalization result in recurrent infections that seriously threaten human health. To overcome these problems, a pH/HO dual-responsive nanoparticle (COSBN@CFS@PS) that can target macrophages, exhibiting synergistic antibiotic and β-lactamase inhibitor activity, is reported. Chitosaccharides (COS) is covalently bound with benzenboronic acid pinacol ester and assemble with cefoxitin sodium salt (CFS) to form COSBN@CFS nanoparticles.
View Article and Find Full Text PDFPurification and Reconstitution of Ilyobacter tartaricus ATP Synthase.
Methods Mol Biol
December 2024
Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt am Main, Germany.
F-type Adenosine triphosphate (ATP) synthase is a membrane-bound macromolecular complex, which is responsible for the synthesis of ATP, the universal energy source in living cells. This enzyme uses the proton- or sodium-motive force to power ATP synthesis by a unique rotary mechanism and can also operate in reverse, ATP hydrolysis, to generate ion gradients across membranes. The FF-ATP synthases from bacteria consist of eight different structural subunits, forming a complex of ~550 kDa in size.
View Article and Find Full Text PDFDiscovery of pentacyclic triterpene conjugates as HBV polymerase/NTCP dual-targeting inhibitors with potent anti-HBV activities.
Bioorg Chem
December 2024
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Guangzhou 510515, China. Electronic address:
The inhibition of HBV DNA and elimination of HBsAg has already been established as an indicator for HBV clinic cure, and a novel dual-targeting inhibitors of HBV polymerase/entry are designed and synthesized in this study. Pentacyclic triterpenes (PTs) scaffold of exhibiting a high affinity to NTCP, including glycyrrhitinic acid (GA), oleanolic acid (OA), ursolic acid (UA), and betulinic acid (BA) were linked neatly with the nucleoside drug zidovudine (AZT) through a molecular hybrid strategy to synthesize twenty of PTs-AZT conjugates for targeting HBV polymerase as well as sodium taurocholate cotransporting polypeptide (NTCP). The conjugates showed significant inhibitory effects on the secretion of HBsAg and HBeAg in HepG2.
View Article and Find Full Text PDFExploring the gelation potentials of chicken heart batter: From by-product to product.
Food Chem
December 2024
Guangdong Provincial Key Laboratory of Food Quality and Safety, National-Local Joint Engineering Research Center for Processing and Safety Control of Livestock and Poultry Products, College of Food Science, South China Agricultural University, Guangzhou 510642, PR China; Universite Paris-Saclay, INRAE, AgroParisTech, UMR SayFood, 91120 Palaiseau, France. Electronic address:
Chicken heart is the by-product of great amount in poultry industry owing to concentrated slaughter development, however, whose potential in food application is unclear. The gelation of chicken heart has great difficulties due to the muscle structure and protein structure of the heart. Therefore, different levels of sodium alginate (SA) were added into chicken heart batter (CHB) to investigate the gelation strategies.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!