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The kinetically-derived maximal dose (KMD) is defined as the maximum external dose at which kinetics are unchanged relative to lower doses, e.g., doses at which kinetic processes are not saturated.
View Article and Find Full Text PDFA pilot study on the effects of olfactory stimulation with white musk aromatic oil on psychophysiological activity: a crossover study.
Sci Rep
January 2025
Department of Agro‑Environmental Sciences, Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi‑ku, Fukuoka, 8190395, Japan.
Studies on the compounds of aromatic oils and their effects on psychophysiological changes in humans are often conducted separately. To obtain better validation, a suitable protocol is needed that can be extrapolated to large-scale olfactory stimulation experiments. Unfortunately, this type of study is still rarely performed.
View Article and Find Full Text PDFFrom Cell to Organ: Exploring the Toxicological Correlation of Organophosphorus Compounds in Living System.
Toxicology
January 2025
Department of Medical Elementology and Toxicology, Jamia Hamdard, Delhi, India, 110062. Electronic address:
Malathion is an organophosphate compound widely used as an insecticide in the agriculture sector and is toxic to humans and other mammals. Although several studies have been conducted at different level in different animal models. But there is no work has been conducted on the toxicological correlation from cellular to behavioral level on surviving species model.
View Article and Find Full Text PDFEmerging Concepts in Periprosthetic Joint Infection Research: The Human Microbiome.
J Arthroplasty
January 2025
International Joint Center, Acibadem University Hospital, Istanbul, Turkey.
Article Synopsis
- The human microbiome consists of microorganisms like bacteria and fungi that impact health, with imbalances (dysbiosis) linked to diseases such as asthma and obesity.
- Current research is exploring how the gut microbiome specifically affects joint health and diseases like osteoarthritis through inflammatory responses triggered by dysbiosis.
- The review aims to enhance our understanding of the microbiome's role in disease and emphasizes the need for further studies on the joint microbiome's impact on conditions like periprosthetic joint infection.
Inhaled ozone induces distinct alterations in pulmonary function in models of acute and episodic exposure in female mice.
Toxicol Sci
January 2025
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, New Jersey, 08854.
Ozone is an urban air pollutant, known to cause lung injury and altered function. Using established models of acute (0.8 ppm, 3 h) and episodic (1.
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