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The brain interactome of a permissive prion replication substrate.
Neurobiol Dis
January 2025
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. Electronic address:
Bank voles are susceptible to prion strains from many different species, yet the molecular mechanisms underlying the ability of bank vole prion protein (BVPrP) to function as a universal prion acceptor remain unclear. Potential differences in molecular environments and protein interaction networks on the cell surface of brain cells may contribute to BVPrP's unusual behavior. To test this hypothesis, we generated knock-in mice that express physiological levels of BVPrP (M109 isoform) and employed mass spectrometry to compare the interactomes of mouse (Mo) PrP and BVPrP following mild in vivo crosslinking of brain tissue.
View Article and Find Full Text PDFAnalysis of Electrical Conductivity in Commercial Adhesives Incorporating Graphene Nanoplatelets for Industrial Applications.
Polymers (Basel)
December 2024
E.T.S. de Ingeniería y Diseño Industrial, Universidad Politécnica de Madrid (España), 28040 Madrid, Spain.
Polymers are often insulators, but this not a universal intrinsic characteristic of all polymers. For this work, the adhesives used, epoxy and polyurethane, do demonstrate this insulating characteristic. However, there has been significant interest in the development of conductive polymers, specifically adhesives, because of the potential properties and ease of processing of these polymers.
View Article and Find Full Text PDFAdhesive damage of class V restorations under shrinkage stress and occlusal forces using cohesive zone modeling.
J Mech Behav Biomed Mater
January 2025
Key Lab for Biomechanical Engineering of Sichuan Province, Sichuan University, Chengdu, China; Sichuan University Yibin Park, Yibin Institute of Industrial Technology, Yibin, China. Electronic address:
Objective: This study aims to investigate adhesive damage caused by the synergistic effects of polymerization shrinkage and occlusal forces via finite element analysis (FEA), based on damage mechanics with the cohesive zone model (CZM). The objective is to obtain the adhesive damage distribution and investigate how the material properties of resin composite impact adhesive damage.
Methods: A 3D reconstruction model of an mandibular first molar was constructed through CBCT imaging, and a Class V cavity was prepared using computer-aided engineering (CAE) software.
Shear Strength of Adhesives Based on Solvent Type, Aged, and LED-cured with Different Wavelengths: An Study.
J Contemp Dent Pract
September 2024
Department of Academic, Faculty of Dentistry, Universidad Nacional Federico Villarreal, Lima, Peru, ORCID: https://orcid.org/0000-0002-0594-5834.
Objective: To evaluate the shear strength of adhesives based on the type of solvent (ethanol and acetone), aged and light-cured using light-emitting diode (LED) units with different wavelengths. Polywave and monowave LED units were employed for this study.
Materials And Methods: Ninety bovine tooth samples were analyzed using OptiBond Universal adhesive (acetone) and single bond universal adhesive (ethanol).
The Effect of Thermocycling on the Shear Bond Strength of Flash-free Brackets and Healing Dynamics of Enamel Microcracks: An Study.
J Contemp Dent Pract
September 2024
Department of Orthodontic, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
Aim: This study evaluates long-term shear bond strength (SBS) and enamel micro cracks (MCs) healing after using adhesive pre-coated brackets (APC).
Materials And Methods: A total of eighty extracted human premolar teeth were randomly divided into four experimental groups ( = 20 per group): Control group: Teeth underwent indentation but no bracket bonding; group II : Teeth were subjected to indentation without exposure to thermocycling; group III: Teeth experienced both indentation and thermocycling; group IV: No indentation was applied to the teeth; groups III and IV were further divided into two subgroups to simulate different clinical timelines: Subgroup A (n = 10): Teeth underwent 5,000 thermocycles, equivalent to six months of clinical use. Subgroup B (n = 10): Teeth were subjected to 10,000 thermocycles, representing 12 months of use.
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