Objective: To compare two intraosseous (IO) insertion devices in terms of safety and ease of use in patients who need urgent vascular access in the emergency setting following failed attempts for intravenous lines.
Methods: This prospective, randomized clinical study compared two different IO access devices in adults (≥16 years of age or weighing>40 kg) admitted to our emergency department with difficult peripheral venous access and in need of urgent intervention. The findings were compared in terms of the rates of successful insertion of spring-loaded impact-driven adult BIG and the battery-driven EZ-IO devices on the first attempt, difficulty of use, time taken to complete the insertion, and complication rates.
Results: A total of 52 patients were enrolled and randomized for the study. IO access was performed in 26 patients using the BIG device and in 26 patients using the EZ-IO device. The rates of successful insertion of BIG and EZ-IO devices on the first attempt were 92.3 and 84.6%, respectively (P=0.668). The time taken to complete the procedure was significantly greater in the EZ-IO group (5.2±2.2 s) compared with the BIG group (2.8±1.2 s) (P<0.001). Difficulty of use was scored using the visual analogue scale, which yielded the mean visual analogue scale for EZ-IO and BIG (25.4±12.6 and 8.6±6.4 mm, respectively) (P<0.001). No mechanical problems or technique-related complications were encountered in any of the groups.
Conclusion: Both EZ-IO and BIG are shown to be reliable and safe methods for insertion of intravascular access in emergency conditions.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/MEJ.0000000000000187 | DOI Listing |
Hum Gene Ther
January 2025
BridgeBio Gene Therapy, Palo Alto, California, USA.
Complement-mediated thrombotic microangiopathy (TMA) in the form of atypical hemolytic uremic syndrome (aHUS) has emerged as an immune complication of systemic adeno-associated virus (AAV) gene transfer that was unforeseen based on nonclinical studies. Understanding this phenomenon in the clinical setting has been limited by incomplete data and a lack of uniform diagnostic and reporting criteria. While apparently rare based on available information, AAV-associated TMA/aHUS can pose a substantial risk to patients including one published fatality.
View Article and Find Full Text PDFErgonomics
January 2025
Department of Systems and Information Engineering, University of Virginia, Charlottesville, VA, USA.
Ergonomics and Human Factors (E/HF) practitioners are increasingly engaged in projects meant to centre underserved communities and reduce inequities. The subdiscipline of E/HF that has emerged to explore the application of E/HF in this way is called community ergonomics. In this qualitative-descriptive study, we reflect on the progress made in the field of community ergonomics since its original conceptualisation in 1994.
View Article and Find Full Text PDFOMICS
January 2025
Department of Biotechnology, Brainware University, Barasat, West Bengal, India.
Next-generation cancer phenomics by deployment of multiple molecular endophenotypes coupled with high-throughput analyses of gene expression offer veritable opportunities for triangulation of discovery findings in non-small cell lung cancer (NSCLC) research. This study reports differentially expressed genes in NSCLC using publicly available datasets (GSE18842 and GSE229253), uncovering 130 common genes that may potentially represent crucial molecular signatures of NSCLC. Additionally, network analyses by GeneMANIA and STRING revealed significant coexpression and interaction patterns among these genes, with four notable hub genes-, , and -identified as pivotal in NSCLC progression.
View Article and Find Full Text PDFActa Obstet Gynecol Scand
January 2025
Department of Women's and Children's Health, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden.
Introduction: Overall childbirth experience scores are used both in research and in clinical settings. Since it is still not fully understood what assessment of childbirth experience on a single-item numeric rating scale or visual analog scale represents, the aim of this study was to explore women's reasoning and thoughts when rating overall childbirth experience numerically.
Material And Methods: A qualitative interview study of 26 women was conducted using a think-aloud technique at a university referral hospital in Sweden.
J Adv Nurs
January 2025
Independant Scholar.
Aim: To explore psychiatric and mental health nurses' perceptions of patients with co-occurring psychiatric and substance use disorders in psychiatric settings.
Design: An exploratory qualitative study design based on grounded theory, employing Straussian analytic procedures.
Method: Semi-structured interviews were conducted with 11 psychiatric and mental health nurses.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!