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A Novel Intravaginal Contraceptive Plug for Cats: A Preliminary Biocompatibility Assessment on Haematology and Vaginal Swab.
Reprod Domest Anim
October 2024
Division of Reproduction, Obstetrics and Gynaecology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Jalan Agathis, Kampus IPB Dramaga, Bogor, West Java, Indonesia.
Article Synopsis
- * Blood analysis showed no significant changes in important haematological parameters after plugging, while vaginal cytology displayed mild inflammation in just one cat on day three, but overall, the cell types remained stable.
- * The results suggest that the PEG 4000 and chitosan-based contraceptive plug is biocompatible and could be a promising contraceptive method for cats.
Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin-Quercetin Inclusion Complex Nanofibers.
ACS Appl Bio Mater
August 2024
Fiber Science Program, Department of Human Centered Design, College of Human Ecology, Cornell University, Ithaca, New York 14853, United States.
Quercetin, recognized for its antioxidant, anti-inflammatory, and antibacterial properties, faces limited biomedical application due to its low solubility. Cotton, a preferred wound dressing material over synthetic ones, lacks inherent antibacterial and wound-healing attributes and can benefit from quercetin features. This study explores the potential of overcoming these challenges through the inclusion complexation of quercetin with cyclodextrins (CDs) and the development of a nanofibrous coating on a cotton nonwoven textile.
View Article and Find Full Text PDFToward an integrated ethical review process: an animal-centered research framework for the refinement of research procedures.
Front Vet Sci
April 2024
Animal-Computer Interaction Lab, School of Computing and Communications, The Open University, Milton Keynes, United Kingdom.
The involvement of animals in research procedures that can harm them and to which they are deemed unable to consent raises fundamental ethical dilemmas. While current ethical review processes emphasize the application of the 3Rs (Replacement, Reduction, and Refinement), grounded in a human-centered utilitarian ethical approach, a comprehensive ethical review also involves a harm-benefit analysis and the consideration of wider ethical issues. Nevertheless, to our knowledge, approaches are still needed to facilitate the integrative assessment and iterative revision of research designs to improve their ethical value or to identify cases in which using animals is irremediably unethical.
View Article and Find Full Text PDFFunctionalization of cotton nonwoven with cyclodextrin/lawsone inclusion complex nanofibrous coating for antibacterial wound dressing.
Int J Pharm
March 2024
Fiber Science Program, Department of Human Centered Design, College of Human Ecology, Cornell University, Ithaca, NY 14853, United States. Electronic address:
Functionalizing cotton to induce biological activity is a viable approach for developing wound dressing. This study explores the development of cotton-based wound dressing through coating with biologically active nanofibers. Bioactive compounds like lawsone offer dual benefits of wound healing and infection prevention, however, their limited solubility and viability hinder their applications.
View Article and Find Full Text PDFElectrospun Nanofiber Composites for Drug Delivery: A Review on Current Progresses.
Polymers (Basel)
September 2022
Faculty of Pharmacy, MAHSA University, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia.
A medication's approximate release profile should be sustained in order to generate the desired therapeutic effect. The drug's release site, duration, and rate must all be adjusted to the drug's therapeutic aim. However, when designing drug delivery systems, this may be a considerable hurdle.
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