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Response to "Anti-amyloid-beta treatments in Alzheimer's disease: When neurologists turn into cheerleaders".
Clin Neurol Neurosurg
January 2025
University of Southern California, Los Angeles, CA, United States. Electronic address:
Profound Properties of Protein-Rich, Platelet-Rich Plasma Matrices as Novel, Multi-Purpose Biological Platforms in Tissue Repair, Regeneration, and Wound Healing.
Int J Mol Sci
July 2024
Bluetail Medical Group & Podesta Orthopedic Sports Medicine, Naples, FL 34109, USA.
Autologous platelet-rich plasma (PRP) preparations are prepared at the point of care. Centrifugation cellular density separation sequesters a fresh unit of blood into three main fractions: a platelet-poor plasma (PPP) fraction, a stratum rich in platelets (platelet concentrate), and variable leukocyte bioformulation and erythrocyte fractions. The employment of autologous platelet concentrates facilitates the biological potential to accelerate and support numerous cellular activities that can lead to tissue repair, tissue regeneration, wound healing, and, ultimately, functional and structural repair.
View Article and Find Full Text PDFExisting market-available refreshable Braille displays (RBDs) offer limited functionality at a high cost, hindering accessibility for individuals with blindness and visual impairment for teaching and learning purposes. This motivates us to develop a multi-functional, compact, and affordable RBD tailored for educational institutes to enhance teaching and learning experiences. We propose the development of BLISS (Braille Letters and Interactive Shape Screen), a novel RBD, that BLISS presents a unique configuration arrangement of Braille cells that accommodates up to six letters at a time and shapes by reusing the Braille pins.
View Article and Find Full Text PDFAnalysis of the Types of Retracted COVID-19 Articles Published in PubMed-Listed Journals.
South Med J
July 2024
From the Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock.
Objectives: Periodically, medical publications are retracted. The reasons vary from minor situations, such as author attributions, which do not undermine the validity of the data or the analysis in the article, to serious reasons, such as fraud. Understanding the reasons for retraction can provide important information for clinicians, educators, researchers, journals, and editorial boards.
View Article and Find Full Text PDFRE104: Synthesis and Activity of a Novel Serotonergic Psychedelic Prodrug of 4-Hydroxy-,-diisopropyltryptamine.
ACS Chem Neurosci
June 2024
Apple Tree Partners, Cambridge, Massachusetts 02142, United States.
Results from randomized clinical trials of psilocybin in depressive disorders highlight the therapeutic potential of serotonergic psychedelic compounds in mental health disorders. The synthetic 5-hydroxytryptamine 2A receptor agonist 4-hydroxy-,-diisopropyltryptamine (4-OH-DiPT) is structurally similar to psilocin but is reported to have a shorter duration (2-3 h) of psychedelic effects, suggesting the potential for psilocybin-like therapeutic activity with reduced clinical resource burden. Here, we describe the preclinical and translational characterization of RE104, a 4-OH-DiPT prodrug comprising a glutarate moiety designed to cleave rapidly in situ and thus provide reasonable bioavailability of the active drug.
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