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Antimicrobial activity of cobalt imidazolate metal-organic frameworks. | LitMetric

Antimicrobial activity of cobalt imidazolate metal-organic frameworks.

Chemosphere

Department of Chemical Engineering, University of Alcalá, 28871 Alcalá de Henares, Madrid, Spain.

Published: October 2014

AI Article Synopsis

  • Two cobalt imidazolate metal-organic frameworks were tested for their ability to inhibit the growth of harmful bacteria Pseudomonas putida and Escherichia coli.
  • Despite challenging growth conditions, these materials achieved over 50% growth inhibition at concentrations between 5-10 mg/L.
  • The antibacterial effects lasted for at least three months, and these cobalt-based materials can be made using inexpensive and easily available ligands, suggesting a cost-effective option for future antimicrobial applications.

Article Abstract

Two cobalt imidazolate metal-organic frameworks were evaluated as a bactericidal material against the growth of the Gram-negative bacteria Pseudomonas putida and Escherichia coli. Under the most unfavourable conditions, within the exponential growth phase and in the culture media for both microorganisms, the growth inhibition reached over 50% for concentrations of biocidal material in the 5-10mgL(-1) range. The release of metal gives excellent durability with the antibacterial effect persisting after 3months. Both cobalt-based materials can be prepared with simple, cheap and easily accessible commercial ligands, leading to a more affordable possible future application as antimicrobial materials.

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Source
http://dx.doi.org/10.1016/j.chemosphere.2014.05.029DOI Listing

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