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One-pot decarboxylative acylation of N-, O-, S-nucleophiles and peptides with 2,2-disubstituted malonic acids. | LitMetric
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One-pot decarboxylative acylation of N-, O-, S-nucleophiles and peptides with 2,2-disubstituted malonic acids.

Iryna O Lebedyeva Suvendu Biswas Kevin Goncalves Sean M Sileno Ashton R Jackson Kunal Patel Peter J Steel Alan R Katritzky

Chemistry

Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200 (USA), Fax: (+1) 352-392-9199; Department of Chemistry and Physics, Georgia Regents University, 1120 15th Street SCI W3005, Augusta, GA 30912 (USA).

Published: September 2014

Monocarbonyl activation of 2,2-disubstituted malonic acids with benzotriazole leads to decarboxylation of one of the carboxy groups and formation of a CH bond. Intermediate carbonyl benzotriazoles then readily acylate nucleophilic reagents and peptides resulting in libraries of conjugates and peptidomimetics.

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 Source
http://dx.doi.org/10.1002/chem.201403529DOI Listing

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