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Utility of Candidate Genes From an Algorithm Designed to Predict Genetic Risk for Opioid Use Disorder.
JAMA Netw Open
January 2025
Mental Illness Research, Education and Clinical Center, Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania.
Importance: Recently, the US Food and Drug Administration gave premarketing approval to an algorithm based on its purported ability to identify individuals at genetic risk for opioid use disorder (OUD). However, the clinical utility of the candidate genetic variants included in the algorithm has not been independently demonstrated.
Objective: To assess the utility of 15 genetic variants from an algorithm intended to predict OUD risk.
Rural Communities in the Deep South: Examining the Relationship Between Social Function and General Health Perceptions in Older Black Americans.
J Racial Ethn Health Disparities
January 2025
Alabama Life Research Institute, The University of Alabama, Tuscaloosa, AL, USA.
Background: Increased mortality in rural southern areas has persisted and worsened among older Black adults due to high prevalence of chronic conditions combined with limited healthcare access resulting from social and structural factors.
Objective: Our objective was to examine the relationship between general health perceptions, social functioning, mental health, and demographic characteristics among Black adults living in the rural south.
Methods: This cross-sectional study examined health perceptions in older Black Americans residing in four rural towns within Alabama (Clayton, Fort Deposit, Hobson City, and York).
The Challenging Problems of Cancer and Serious Mental Illness.
Curr Psychiatry Rep
January 2025
Institute of Psychiatry, Department of Neuroscience and Rehabilitation, University of Ferrara, Via Fossato di Mortara 64a, Ferrara, 44121, Italy.
PURPOSE OF REVIEW: Patients with Serious Mental Illness (SMI) are reported to be at higher risk for somatic disorders (e.g. cardiovascular and metabolic diseases) and higher mortality, compared to the general population, because of the consequences of SMI including psychotropic medication side effects, sedentary and unhealthy lifestyle, difficult access to physical health care.
View Article and Find Full Text PDFAcute Needs, ACUTE Response: Development and Delivery of a Mental Health Urgent Care in the Bronx.
Community Ment Health J
January 2025
Department of Psychiatry and Behavioral Sciences, Montefiore Medical Center, Bronx, NY, USA.
As mental health needs rise, creative and timely solutions are essential. Leveraging the expansion and flexibility of virtual services to create telehealth and hybrid offerings is crucial for addressing systemic barriers in mental health, enhancing accessibility, and providing flexible, comprehensive care options for diverse patient populations. This article discusses the development of a mental health urgent care program within a large medical system in a densely populated, under-resourced community.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Amsterdam Neuroscience, Neurodegeneration, Amsterdam, Netherlands.
Background: We hypothesise that improved diagnostic precision, operationalised by adding amyloid positron emission tomography (PET) to the diagnostic work-up in a memory clinic, is beneficial for long-term health and healthcare cost outcomes. We investigated whether a more precise diagnosis influenced institutionalisation and mortality incidence trajectories, and annual healthcare costs over a period up to eight years.
Method: Between October 2014 and December 2016, patients from the Amsterdam Dementia Cohort were offered an amyloid-PET as part of their diagnostic work-up.
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