How wakefulness shapes neural activity is a topic of intense discussion. In the awake olfactory bulb, high activity with weak sensory-evoked responses has been reported in mitral/tufted cells (M/TCs). Using blind whole-cell recordings, we found 33% of M/TCs to be 'silent', yet still show strong sensory responses, with weak or inhibitory responses in 'active' neurons. Thus, a previously missed M/TC subpopulation can exert powerful influence over the olfactory bulb.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176944 | PMC |
| http://dx.doi.org/10.1038/nn.3768 | DOI Listing |
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