Leukocyte chemotactic factor 2 (LECT2) amyloidosis is a recently identified type of amyloidosis that may represent an underdiagnosed cause of chronic kidney disease. LECT2 amyloidosis typically is reported as being renal limited and, in the United States, more prevalent in Hispanic patients. We add to the epidemiologic data of this condition by describing 4 First Nations people from Northern British Columbia, Canada, who presented with slowly progressive chronic kidney disease that was found to be due to LECT2 amyloidosis.
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Kidney Disease in Systemic Amyloidosis: A Review of Amyloid, Amyloid Serum A Protein, Leukocyte Chemotactic Factor 2, and Transthyretin Amyloid.
Kidney360
December 2024
Department of Nephrology, Centro Hospitalar Universitário de Santo António (CHUdSA), Porto, Portugal.
Article Synopsis
- * Light chain amyloid is the most commonly researched form of renal amyloid, but there's increasing interest in less common types like serum A protein, leukocyte chemotactic factor 2, and transthyretin amyloid.
- * This review discusses recent advancements in diagnosis, the effects on kidney function, and the treatments available for these specific amyloid types.
[Renal leukocyte chemokine type 2 amyloidosis: a clinicopathological analysis of fifteen cases].
Zhonghua Bing Li Xue Za Zhi
August 2024
Department of Pathology, Shanxi Medical University Second Hospital, Taiyuan 030001, China.
To investigate the clinicopathological features of renal leukocyte chemokine type 2 amyloidosis (ALECT2). The prevalence, clinical characteristics, renal histopathological features, and renal outcome of 15 patients with ALECT2 by kidney biopsy were collected in the Department of Kidney Pathology, Shanxi Medical University Second Hospital, Taiyuan, China from January 1993 to December 2023. Immunohistochemistry and mass spectrometry for amyloid proteins were carried out.
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Front Immunol
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Development and Regeneration Key Laboratory of Sichuan Province, Institute of Neuroscience, Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, China.
Leukocyte cell-derived chemotaxin-2 (LECT2) is an important cytokine synthesized by liver. Significant research interest is stimulated by its crucial involvement in inflammatory response, immune regulation, disease occurrence and development. However, bibliometric study on LECT2 is lacking.
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Am J Nephrol
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Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Background: Amyloidosis includes a diverse group of rare diseases characterized by the misfolding of native or mutant proteins, leading to extracellular accumulation in various organs. While 42 proteins have been identified to date, their distribution differs between systemic and localized forms.
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ALECT2 amyloidosis with concurrent IgG4-related interstitial nephritis, membranous nephropathy and diabetic kidney disease: a case report and literature review.
J Nephrol
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Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Leukocyte chemotactic factor-2 amyloidosis (ALECT2) is a recently described subtype of amyloidosis. IgG4-related disease is a rare fibroinflammatory condition characterized by dense interstitial lymphoplasmacytic infiltrates and fibrosis. Membranous nephropathy and diabetic nephropathy are common causes of nephrotic syndrome.
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