AI Article Synopsis
- The study investigates cytokine production in human tonsillar lymph follicles during germinal center reactions, focusing on B and T lymphoid cells along with macrophages and follicular dendritic cells.
- Key findings include the detection of IL-6 and TNF in cultures stimulated with specific mitogens, while IL-1 beta's presence varied based on tonsil origin and cell type.
- Follicular dendritic cell-containing populations produced higher levels of IL-6 and TNF compared to those with only B and T cells, indicating their significant role in cytokine production.
Article Abstract
The events occurring inside lymph follicles during a germinal center reaction are poorly understood. Using B and T lymphoid cell populations prepared from human tonsillar lymph follicles, and enriched or not in macrophages or in follicular dendritic cells, we examined the production of cytokines by these cells in vitro. Interleukin 6 (IL-6) and tumor necrosis factor (TNF) were found in the supernatants of cultures stimulated with phytohemagglutinin or pokeweed mitogen. IL-1 beta was occasionally detected; its secretion apparently depends on the origin of the tonsils, the stimulation, and the cell populations. IFN-gamma and IL-2 were not produced in significant amounts by these lymph follicle cells. IL-4 was only found in very low concentrations in the supernatant of the different cell cultures. The cell populations containing follicular dendritic cells produced more IL-6 and TNF than the others, especially than those composed of only B and T cells.
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| http://dx.doi.org/10.1016/0165-2478(89)90179-x | DOI Listing |
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