AI Article Synopsis
- A study investigated how diabetes mellitus (DM) affects the survival of early-stage colon cancer patients who had curative surgery, using data from Taiwan.
- The research analyzed 6,937 patients, revealing that those with DM had a lower overall survival rate (5-year OS: 71.0%) compared to those without (5-year OS: 81.7%).
- Even after considering other factors, DM independently predicted higher overall mortality but not cancer-specific mortality, with patients on insulin experiencing the worst survival outcomes.
Article Abstract
Background: We investigated the association between diabetes mellitus (DM) and the prognosis of patients with early colon cancer who had undergone curative surgery.
Methods: From three national databases of patients in Taiwan, we selected a cohort of colon cancer patients who had been newly diagnosed with stage I or stage II colon cancer between January 1, 2004 and December 31, 2008 and had undergone curative surgery. We collected information regarding DM (type 2 DM only), the use of antidiabetic medications, other comorbidities, and survival outcomes. The colon cancer-specific survival (CSS) and the overall survival (OS) were compared between patients with and without DM.
Results: We selected 6,937 colon cancer patients, among whom 1,371 (19.8%) had DM. The colon cancer patients with DM were older and less likely to receive adjuvant chemotherapy but had a similar tumor stage and grade, compared with colon cancer patients without DM. Compared with colon cancer patients without DM, patients with DM had significantly shorter OS (5-year OS: 71.0% vs. 81.7%) and CSS (5-year CSS: 86.7% vs. 89.2%). After adjusting for age, sex, stage, adjuvant chemotherapy, and comorbidities in our multivariate analysis, DM remained an independent prognostic factor for overall mortality (adjusted hazards ratio: 1.32, 95% confidence interval: 1.18-1.49), but not for cancer-specific mortality. Among the colon cancer patients who had received antidiabetic drug therapy, patients who had used insulin had significantly shorter CSS and OS than patients who had not.
Conclusion: Among patients who receive curative surgery for early colon cancer, DM is a predictor of increased overall mortality.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153450 | PMC |
| http://dx.doi.org/10.1634/theoncologist.2013-0423 | DOI Listing |
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