Background: The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established.
Methods: We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection.
Results: The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (p = .001). The rate of occult nodal metastases was 17%. Overall 5-year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (p = .017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival.
Conclusion: Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988229 | PMC |
| http://dx.doi.org/10.1002/hed.23711 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Revealing the Enigma: A Deep Dive Into Submandibular Adenoid Cystic Carcinoma and Its Management.
Cureus
November 2024
Radiation Oncology, Faculty of Medicine and Pharmacy - Mohammed First University, oujda, MAR.
Adenoid cystic carcinoma (ACC) of the submandibular gland is a rare and highly aggressive malignancy, distinguished by its tendency for perineural invasion and distant metastasis, particularly to the lungs and bones. The management of ACC is challenging due to its biological variability and the absence of specific randomized controlled trials to guide treatment. This report aims to encapsulate the clinical features, histological profile, diagnostic workup, and management options for submandibular gland ACC, with an emphasis on recent advancements in understanding and treatment.
View Article and Find Full Text PDF[Adenoid cystic carcinoma of the maxillary sinus and lateral skull base was removed and the submental artery island flap repaired the hard palate: a case report].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
January 2025
Adenoid cystic carcinoma is a malignant tumor of the head and neck, this article reports a case of a large adenoid cystic carcinoma of the skull base, with the lesion involving the sphenoid sinus, sphenoid bone wings, pterygopalatine fossa, nfratemporal fossa, hard palate, and other structures. The treatment plan consisted of surgical excision, primary reconstrction of the surgical defect,and postoperative radiotherapy, resulting in a favorable prognosis for the patient.
View Article and Find Full Text PDFMULTIPLE MUSHROOM-LIKE GROWING CYLINDROMAS OF THE SCALP (TURBAN TUMOR) IN A PATIENT WITH BROOKE-SPIEGLER SYNDROME: UNIQUE MANIFESTATION IN A BULGARIAN PATIENT.
Georgian Med News
October 2024
1Onkoderma - Clinic for Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
Cutaneous cylindromas are rare, slow-growing adnexal tumors commonly found on the capillitium or face. When located on the capillitium, they can cluster together, forming a headgear-like structure that gives the characteristic "turban" appearance. Brooke-Spiegler syndrome, an autosomal dominant condition, is typically benign, though malignant transformation can occur.
View Article and Find Full Text PDFA Benign Lesion of Thyroid Masquerading as a Salivary Gland Malignancy on Cytology.
Diagn Cytopathol
December 2024
Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Introduction: Thyroid lesions are one of the most common diseases observed in clinical practice in the North India. These diseases have distinct cytological morphology and thus FNAC is done frequently. Here we report a case of adenomatoid goitre mimicking adenoid cystic carcinoma (ACC) of salivary gland on cytology.
View Article and Find Full Text PDFAdenoid cystic carcinoma in the nasolacrimal duct: a case report.
J Int Med Res
December 2024
Department of Pathology, Chungbuk National University Hospital, Cheongju, Korea.
Adenoid cystic carcinoma (ACC) rarely occurs in the nasolacrimal duct (NLD), and when it does, it has nonspecific manifestations. To the best of our knowledge, one case of ACC in the NLD has been reported in the literature. Herein, we report a second case of ACC in the left NLD, concerning a man in his late 60s.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!