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Artificial Intelligence-Driven Precision Medicine: Multi-Omics and Spatial Multi-Omics Approaches in Diffuse Large B-Cell Lymphoma (DLBCL).
Front Biosci (Landmark Ed)
November 2024
Department of Hematology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, 317000 Taizhou, Zhejiang, China.
In this comprehensive review, we delve into the transformative role of artificial intelligence (AI) in refining the application of multi-omics and spatial multi-omics within the realm of diffuse large B-cell lymphoma (DLBCL) research. We scrutinized the current landscape of multi-omics and spatial multi-omics technologies, accentuating their combined potential with AI to provide unparalleled insights into the molecular intricacies and spatial heterogeneity inherent to DLBCL. Despite current progress, we acknowledge the hurdles that impede the full utilization of these technologies, such as the integration and sophisticated analysis of complex datasets, the necessity for standardized protocols, the reproducibility of findings, and the interpretation of their biological significance.
View Article and Find Full Text PDFNeuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children.
J Integr Neurosci
December 2024
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06519, USA.
Background: The National Institutes of Health (NIH) Toolbox Cognition Battery is increasingly being used as a standardized test to examine cognitive functioning in multicentric studies. This study examines the associations between the NIH Toolbox Cognition Battery composite scores with neuroimaging metrics using data from the Adolescent Brain Cognitive Development (ABCD) study to elucidate the neurobiological and neuroanatomical correlates of these cognitive scores.
Methods: Neuroimaging data from 5290 children (mean age 9.
Current and Emerging Techniques for Diagnosis of Toxoplasmosis in Pregnancy: A Narrative Review.
Iran J Parasitol
January 2024
Center for Research of Endemic Parasites of Iran, Tehran University of Medical Sciences, Tehran, Iran.
is an intracellular parasite capable of crossing the placenta in pregnancy and infecting the developing fetus, leading to various congenital anomalies and even abortion. Acute infection is responsible for almost all cases of congenital toxoplasmosis in immunocompetent pregnant women. Prenatal screening for acute toxoplasmosis primarily involves maternal serology and fetal ultrasound imaging.
View Article and Find Full Text PDFEnhancing Reflective Practice Using Prompts in Online Submission of Case Reports (OSCAR): An Exploratory Study Among Medical Students in Rural Longitudinal Integrated Clerkships.
Perspect Med Educ
December 2024
Griffith University Rural Clinical School, Toowoomba, Australia.
Introduction: Medical students learn to reflect to gain new insights into self and practice; however, allowing for reflection within a busy curriculum is challenging. In this study we embedded reflective writing prompts (RWP) into an existing assessment item, Online Submission of Case Reports (OSCAR), to investigate whether this minimalistic scaffolding intervention could develop students' reflective capacity and increase their exposure to rural social determinants of health.
Methods: This study is framed by ontological realism and informed by an interpretivist stance.
Case Finding and Management of Childhood Cataracts: The Role of a Child Eye Health Programme in Kaduna State, Nigeria.
J West Afr Coll Surg
August 2024
International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, UK.
Objective: To evaluate the output of a child eye health programme in terms of identification, referral, and volume of paediatric cataract surgeries in Kaduna State, Nigeria.
Materials And Methods: This was a retrospective review of the North-West Nigeria Child Eye Health Initiative programme referral registers at primary, secondary and tertiary hospitals in Kaduna State. Theatre registers of children 0-16 years who had cataract surgery at National Eye Centre Kaduna between 2016 and 2019 were also reviewed.
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