AI Article Synopsis
- * Catabolite control protein A (CcpA) is a key regulator that influences bacterial growth on glucose or galactose and affects how bacteria metabolize nutrients, impacting their virulence.
- * A study using metabolomics revealed 37 metabolites that differed between the native type 2 bacteria and a CcpA mutant, highlighting the importance of CcpA in understanding bacterial protein functions.
Article Abstract
() type 2 is an extremely important Gram-positive bacterial pathogen that can cause human or swine endocarditis, meningitis, bronchopneumonia, arthritis and sepsis. Catabolite control protein A (CcpA) is a major transcriptional regulator in type 2 that functions in catabolite control, specifically during growth on glucose or galactose. The regulation of central metabolism can affect the virulence of bacteria. In the present study, a metabolomics approach was used along with principal components analysis (PCA) and partial least-squares-discriminant analysis (PLS-DA) models and 37 metabolites were found that differed substantially between native and a mutant lacking CcpA. These results showed that CcpA is an important protein in type 2 for studying bacterial protein function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106511 | PMC |
| http://dx.doi.org/10.3892/br.2014.307 | DOI Listing |
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