Objective: To investigate the prevalence and characteristics of primary glaucoma in the population of Huamu community, Shanghai.
Methods: It was a population-based cross-section study.Using random cluster sampling method, 3 neighborhood committees were randomly selected from Huamu community. And this survey was carried out by screening in community combined with diagnosis in tertiary hospital from March to September 2011. Residents aged more than 50 years old were included in this study.Information was collected on the participants' presenting visual acuity with habitual correction and best corrected visual acuity, intraocular pressure (IOP) assessed with non-contact tonometer, ocular anterior segment examination results with slit lamp anterior segment photography, optic disc examination results with fundus photography. And all glaucoma suspects received IOP measurement, gonioscopy, visual field test, retinal nerve fiber layer thickness measurement in Shanghai Eye Disease Prevention and Treatment center.Glaucoma was diagnosed according to International Society for Geographic and Epidemiological Ophthalmology. Distributions of different types of primary glaucoma within different groups of gender and age were described, and prevalence rates of primary glaucoma between different groups were compared using chi-square test.
Results: Two thousands five hundreds and twenty-eight cases were examined and the respond rate was 80.36%. Prevalence of primary glaucoma was 3.09%, in which primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) were 2.85% and 0.24%. The prevalence of POAG had upward trend with age. The blindness rate within one or both eyes caused by POAG and PACG was 12.5% and 3/6, and the blindness rate of POAG was lower compared with PACG. 88.89% of POAG in this investigation had not been previously diagnosed, and 100% of PACG had been previously diagnosed and received treatment.
Conclusions: The prevalence of primary glaucoma in Huamu community is relatively high and the previous diagnostic and treatment rate of POAG are relatively low. Early screening and health education for primary glaucoma are important in blindness prevention work in the future.
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Jpn J Ophthalmol
January 2025
Department of Ophthalmology, Graduate of Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Purpose: To assess the efficacy and safety of PreserFlo MicroShunt (PMS) combined with mitomycin C in patients with medically treated primary open-angle glaucoma (POAG).
Study Design: A retrospective observational study.
Methods: The study examined 83 eyes from 83 patients with medically treated glaucoma surgery naive POAG.
BMC Ophthalmol
January 2025
Department of Ophthalmology, Medical Faculty, University Hospital of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Background/ Aims: To analyze the longitudinal change in Bruch's membrane opening minimal rim width (BMO-MRW) and peripapillary retinal nerve fiber layer (pRNFL) thickness using optical coherence tomography (OCT) after implantation of a PRESERFLO® microshunt for surgical glaucoma management in adult glaucoma patients.
Methods: Retrospective data analysis of 59 eyes of 59 participants undergoing implantation of a PRESERFLO microshunt between 2019 and 2022 at a tertiary center for glaucoma management. Surgical management included primary temporary occlusion of the glaucoma shunt to prevent early hypotony.
J Pediatr
January 2025
Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy; NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, Duke Eye Center, Duke University, Durham, North Carolina, United States.
Purpose: To study the roles of tubulin acetylation and cyclic mechanical stretch (CMS) in trabecular meshwork (TM) cells and their impact on outflow pathway physiology and pathology.
Methods: Primary TM cell cultures were subjected to CMS (8% elongation, 24 hours), and acetylated α-tubulin at lysine 40 (Ac-TUBA4) was assessed by western blotting and immunofluorescence. Enzymes regulating tubulin acetylation were identified via siRNA-mediated knockdowns of ATAT1, HDAC6, and SIRT2.
BMJ Open
January 2025
Department of Optometry, College of Medicine and Health Sciences, Comprehensive Specialized Hospital, University of Gondar, Gondar, Ethiopia.
Objective: Adaptive coping mechanisms (ACMs) are effective ways to cope with stress and anxiety in patients with chronic illnesses, such as glaucoma. This study aimed to assess the proportion of ACM and associated factors among adult glaucoma patients enrolled at the tertiary eye care and training centre in Northwest Ethiopia.
Design: An institution-based cross-sectional study.
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