AI Article Synopsis
- There is a connection between vitamin D levels and the prevalence of obesity and type 2 diabetes, but the exact causality is not clear yet.
- A study was conducted using mice to investigate if vitamin D3 supplementation could prevent obesity caused by a high-fat diet.
- The results indicated that vitamin D3 helped limit weight gain and improved blood sugar control, likely by enhancing fat oxidation and boosting energy expenditure, suggesting its potential role in preventing obesity and metabolic issues.
Article Abstract
Prospective studies reported an inverse correlation between 25-hydroxyvitamin D [25(OH)D] plasma levels and prevalence of obesity and type 2 diabetes. In addition, 25(OH)D status may be a determinant of obesity onset. However, the causality between these observations is not yet established. We studied the preventive effect of vitamin D3 (VD3) supplementation (15,000 IU/kg of food for 10 weeks) on onset of obesity in a diet-induced obesity mouse model. We showed that the VD3 supplementation limited weight gain induced by high-fat diet, which paralleled with an improvement of glucose homeostasis. The limitation of weight gain could further be explained by an increased lipid oxidation, possibly due to an up-regulation of genes involved in fatty acid oxidation and mitochondrial metabolism, leading to increased energy expenditure. Altogether, these data show that VD3 regulates energy expenditure and suggest that VD3 supplementation may represent a strategy of preventive nutrition to fight the onset of obesity and associated metabolic disorders.
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| http://dx.doi.org/10.1016/j.jnutbio.2014.05.010 | DOI Listing |
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