AI Article Synopsis

  • Glioma is a type of brain cancer that is very difficult to treat and doesn't usually allow patients to live longer.
  • Scientists found that a pathway called WNT is important for the growth and spread of glioma, so targeting this pathway might help fight the cancer.
  • A new treatment using a modified virus to boost the levels of a protein called TIKI2 in glioma cells showed promise in reducing cancer growth without harming normal cells, suggesting it could be a good option for future studies.

Article Abstract

Glioma is the most common brain malignancy and has a very poor prognosis. The current treatment options have a minimal benefit on prolonging patient survival time. Accumulating data have shown that the WNT signaling pathway has a critical function in the progression and invasion of glioma. Thus, targeting WNT signaling appears to be an effective anti‑glioma strategy. TIKI2 was recently found to suppress the activation of the WNT signaling pathway by post‑translationally modifying secreted WNT proteins. The implication of TIKI2 aberrance in cancers and its potential therapeutic effect, however, has not been studied. In the present study, a glioma‑specific adenoviral vector was constructed, which was regulated by response elements of miR‑124, to express TIKI2 in glioma cells (Ad‑TIKI2‑124). Ad‑TIKI2‑124 was found to potently suppress the activation of WNT signaling in glioma cells. This inhibitory effect on the WNT signaling pathway lead to the reduction in proliferation, colony formation ability and invasion of glioma cell lines. In addition, animal experiments confirmed that the expression of the Ad‑TIKI2‑124 construct could compromise the tumorigenicity of glioma cells in vivo. Furthermore, this glioma‑selective TIKI2 expression protected normal cells from toxicity. In conclusion, the present study demonstrated that adenovirus‑mediated TIKI2 therapy may be used for glioma treatment and therefore warrants further clinical studies.

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2014.2412DOI Listing

Publication Analysis

Top Keywords

wnt signaling
20
signaling pathway
12
glioma cells
12
tiki2 expression
8
invasion glioma
8
suppress activation
8
activation wnt
8
glioma
7
tiki2
6
wnt
6

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!