AI Article Synopsis
- The study assessed the effectiveness of two antifungal drugs, voriconazole (VRC) and posaconazole (PSC), against Candida guilliermondii in lab experiments.
- Both drugs demonstrated fungistatic effects, meaning they can inhibit the growth of the fungus, and reduced fungal levels in the kidneys of mice with a weakened immune system.
- Posaconazole was found to be significantly more effective than voriconazole against one of the fungal strains tested, with both drugs showing effective serum levels.
Article Abstract
We evaluated the in vitro killing activity of voriconazole (VRC) and posaconazole (PSC) against two clinical isolates of Candida guilliermondii. The two drugs showed fungistatic activity against both isolates and were effective in reducing kidney fungal burden in a neutropenic murine model of disseminated candidiasis in infected mice. PSC was significantly more effective than VRC against one of the strains. The serum levels of PSC and VRC were above the corresponding MICs for these isolates.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187986 | PMC |
| http://dx.doi.org/10.1128/AAC.03051-14 | DOI Listing |
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