Four tetracationic porphyrins have been investigated for their ability to photo-inactivate Leishmania major promastigotes. Parallel photocytotoxicity assays against keratinocytes and macrophages show significant differences in activity between the microorganism and mammalian cells. Results suggest that it may be possible to photodynamically inactivate macrophages infected with Leishmania and the promastigote form of the microorganism, while minimising damage to surrounding tissue.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pdpdt.2006.04.004 | DOI Listing |
Publication Analysis
Top Keywords
potential cationic
4
cationic porphyrins
4
porphyrins photodynamic
4
photodynamic treatment
4
treatment cutaneous
4
cutaneous leishmaniasis
4
leishmaniasis tetracationic
4
tetracationic porphyrins
4
porphyrins investigated
4
investigated ability
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!