During the processing of meat and meat products the generation of undesirable compounds can occur. Known examples are the generation of substances that can lead to a negative effect on the texture, flavour or colour of products after processing or during storage. Furthermore, thermal processing and smoking have been associated with the generation of or contamination with toxic substances, e.g. polycyclic aromatic hydrocarbons or heterocyclic amines. The introduction of new processing technologies may result in the formation of different undesirable compounds compared to traditional technologies. Some of these changes may be without relevant nutritional or health impact, while others may raise concern. To begin with, an overview on the formation of undesirable process-induced compounds by the traditional processing of meat and the proposed strategies for their reduction is presented. Hereby attention is mainly paid to those compounds which present human health concerns. Later the focus lays on the process-induced modifications occurring in meat as a result of high hydrostatic pressure treatments.
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http://dx.doi.org/10.1016/j.meatsci.2014.06.038 | DOI Listing |
In Silico Pharmacol
January 2025
Department of Biotechnology and Bioinformatics, JSS Academy of Higher Education and Research, Mysore, Karnataka 570015 India.
Unlabelled: Parkinson's Disease (PD) is a neurodegenerative disorder that primarily affects persons aged 65 and older. It leads to a decline in motor function as a result of the buildup of abnormal protein deposits called Lewy bodies in the brain. Existing therapies exhibit restricted effectiveness and undesirable side effects.
View Article and Find Full Text PDFRecent Adv Drug Deliv Formul
January 2025
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Biosci Biotechnol Biochem
January 2025
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan.
Protein kinase C (PKC) is a family of serine/threonine kinases, and PKC ligands have the potential to be therapeutic seeds for cancer, Alzheimer's disease, and human immunodeficiency virus infection. However, in addition to desired therapeutic effects, most PKC ligands also exhibit undesirable pro-inflammatory effects. The discovery of new scaffolds for PKC ligands is important for developing less inflammatory PKC ligands, such as bryostatins.
View Article and Find Full Text PDFPharmaceuticals (Basel)
January 2025
School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
DPP4 is an enzyme with multiple natural substrates and probable involvement in various mechanisms. It constitutes a drug target for the treatment of diabetes II, although, also related to other disorders. While a number of drugs with competitive inhibitory action and covalent binding capacity are available, undesired side effects exist partly attributed to drug kinetics, and research for finding novel, potent, and safer compounds continues.
View Article and Find Full Text PDFMolecules
January 2025
Department of Pharmacology, Animal Physiology Biochemistry and Chemistry, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria.
The interpretation of the biochemistry of immune metabolism could be considered an attractive scientific field of biomedicine research. In this review, the role of glycolysis in macrophage polarization is discussed together with mitochondrial metabolism in cancer cells. In the first part, the focus is on the Warburg effect and redox metabolism during macrophage polarization, cancer development, and management of the immune response by the cancer cells.
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