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Fluorescence induced by aminolevulinic acid and methyl aminolevulinate on normal skin. | LitMetric
Background : PDT is a treatment modality, which uses a combination of a photosensitising drug, oxygen and light to selectively destroy pre-malignant and malignant tissue. The most commonly used PDT photosensitiser precursor is 5-aminolevulinic acid (ALA). However recently the introduction of methyl aminolevulinate (MAL) another topical photosensitiser has posed the question of which may be of greater clinical advantage when used in PDT.Aims : The characteristics of PpIX fluorescence following the application of different quantities of both ALA and MAL were investigated in normal skin.Methods : PpIX fluorescence was detected using a non-invasive spectroscopy system. A total of 17 healthy volunteers were recruited, and varying quantities of both ALA and MAL were applied to the inner forearm.Results And Conclusions : Topical application (within the range of 0.01-0.09ml) of both ALA and MAL to normal human skin-induced PpIX fluorescence. This induced fluorescence was not dose dependent within the range investigated. However, the time course and intensity of fluorescence was significantly different for ALA and MAL. PpIX-induced fluorescence peaked at 7h following the application of MAL, compared to 24h following the application of ALA. At all time points, ALA-induced fluorescence was significantly greater than that induced by MAL. These results help define some of the characteristics of ALA- and MAL-induced PpIX fluorescence in normal skin.
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